Cooling system for a photocosmetic device

ABSTRACT

Photocosmetic device for use in medical or non-medical environments (e.g., a home, barbershop, or spa), which can be used for a variety of tissue treatments. Radiation is delivered to the tissue via optical systems designed to pattern the radiation and project the radiation to a particular depth. The device has a variety of cooling systems including phase change cooling solids and liquids to cool treated skin and the radiation sources. Contact sensors and motion sensor may be used to enhance treatment. The device may be modular to facilitate manufacture and replacement of parts.

RELATED APPLICATIONS

This application is a continuation of application Ser. No. 13/443,381,(“the '381 application”), filed Apr. 10, 2012, which is a continuationof application Ser. No. 11/603,712 (“the '712 application”), filed Nov.22, 2006, which is a continuation application of Ser. No. 10/154,756(“the '756 application”), now U.S. Pat. No. 7,204,832, filed May 23,2002, which claims priority to provisional application Ser. No.60/363,798, filed Mar. 12, 2002. The '756 application is also acontinuation-in-part of application Ser. No. 10/052,474, filed Jan. 18,2002, now U.S. Pat. No. 6,663,620, which application is a continuationof application Ser. No. 09/473,910, now U.S. Pat. No. 6,517,532, filedDec. 28, 1999, which application claims priority to provisionalapplication Ser. No. 60/115,447, filed Jan. 8, 1999, claims priorityfrom provisional application Ser. No. 60/164,492, filed Nov. 9, 1999,and is a continuation-in-part of application Ser. No. 09/078,055, filedMay 13, 1998, now U.S. Pat. No. 6,273,884, which application claimspriority to provisional application Ser. No. 60/046,542, filed May 15,1997 and provisional application Ser. No. 60/077,726, filed Mar. 12,1998. The '756 application is also a continuation-in-part of applicationSer. No. 09/268,433, filed Mar. 12, 1999, now U.S. Pat. No. 6,508,813,which application claims priority to provisional application Ser. No.60/115,447, filed Jan. 8, 1999 and provisional application Ser. No.60/077,794, filed Jan. 8, 1999 and is a continuation-in-part ofapplication Ser. No. 08/759,036, filed Dec. 2, 1996, now U.S. Pat. No.6,015,404, and is a continuation-in-part of application Ser. No.08/759,136, filed Dec. 2, 1996, now abandoned, and is acontinuation-in-part of application Ser. No. 09/078,055, filed May 13,1998, now U.S. Pat. No. 6,273,884, which application claims priority toprovisional application Ser. No. 60/046,542, filed May 15, 1997 andprovisional application Ser. No. 60/077,726, filed Mar. 12, 1998. The'756 application is also a continuation-in-part of application Ser. No.09/634,981, filed Aug. 9, 2000, now U.S. Pat. No. 6,511,475, whichapplication is a continuation of application Ser. No. 09/078,055, filedMay 13, 1998, now U.S. Pat. No. 6,273,884, which application claimspriority to provisional application Ser. No. 60/046,542, filed May 15,1997 and provisional application Ser. No. 60/077,726, filed Mar. 12,1998. The '756 application is also a continuation-in-part of applicationSer. No. 09/847,043, filed Apr. 30, 2001, now U.S. Pat. No. 6,653,618which claims priority to provisional application Ser. No. 60/200,431,filed Apr. 28, 2000. The '756 application also claims priority toprovisional application Ser. No. 60/292,827, filed May 23, 2001. The'756 application also claims priority to provisional application Ser.No. 60/363,871, filed Mar. 12, 2002. The contents of all of these priorapplication specifications are incorporated herein by reference.

BACKGROUND OF THE INVENTION Related Art

There exists a variety of conditions treatable using photocosmeticprocedures (also referred to herein as photocosmetic treatments),including light-based (e.g., using a laser or lamp) hair removal,treatment of various skin lesions, tattoo removal, facial resurfacing,and skin rejuvenation. Currently, photocosmetic procedures are performedusing professional-grade devices that cause destructive heating oftarget structures located in the epidermis/dermis of a patient's skin.

To date, photocosmetic procedures have been performed in adermatologist's office, partially because of the expense of the devicesused to perform the procedures, partially because of safety concernsrelated to the devices, and partially because of the need to care foroptically induced wounds on the patient's skin. Such wounds may arisefrom damage to a patient's epidermis caused by the high-power radiationand may result in significant pain and/or risk of infection. Whilecertain photocosmetic procedures, such as CO₂ laser facial resurfacing,will continue to be performed in the dermatologist's office for medicalreasons (e.g., the need for post-operative wound care), there are alarge number of photocosmetic procedures that could be performed in anon-medical environment (e.g., home, barber shop, or spa) if theconsumer could perform the procedure in a safe and effective manner.Even for procedures performed in a medical environment, reduced skindamage would reduce recovery time.

Photocosmetic devices for use in medical or non-medical environments maybenefit from following characteristics: (1) The device must be safe. Forexample, it is necessary to avoid eye and skin injuries. (2) Preferablythe device is easy to use, thus allowing an operator to achieveacceptable cosmetic results after only reading a brief training period.(3) Preferably the device is robust and rugged enough to withstandabuse. (5) Preferably the device is easy to maintain. (6) Preferably thedevice is manufacturable in high volume. (7) Preferably the device isavailable at a reasonable price. (8) Preferably the device is small andeasily stored, for example, in a bathroom. Currently availablephotocosmetic devices have limitations related to one or more of theabove challenges.

SUMMARY OF THE INVENTION

A first aspect of the invention is a photocosmetic device for use on anarea of a patient's skin comprising a treatment head for use in closeproximity to the patient's skin, at least one source of electromagneticradiation positioned within the treatment head and configured to projectradiation onto the area of skin, a cooling surface thermally coupled tothe at least one source, and a mechanism to direct a phase changesubstance onto the cooling surface. Optionally, the phase changesubstance comprises a liquid. Alternatively, the phase change substancecomprises a solid.

In some embodiments of the first aspect, the surface has a texture. Thetexture may be a linear groove pattern or a concentric groove pattern.Alternatively, the texture is a plurality of projections. The mechanismmay be a spray jet. The mechanism may further comprise a valve coupledto the spray jet, wherein the valve controls the amount of liquidprojected onto the cooling surface. A heat sensor may be used to producea signal indicative of the temperature of at least a portion of the areaof skin, and a controller maybe be used to receive the signal from theheat sensor and control the valve in response to the temperature.

A container may be included to hold the substance. In some embodiments,the substance is a refrigerant. For example, the refrigerant comprisestetra flouroethane. The solid may be ice or an organic compound, or anGa/In alloy.

The cooling surface may be a thermally conductive electrode providingpower to the source. Alternatively, the cooling surface may be a surfaceof a thermally conductive heat sink that is thermally coupled to thesource. The cooling surface may have at least one channel therethroughto receive the phase change substance. Alternatively, the coolingsurface has a plurality of channels therethrough to receive the phasechange substance, the plurality of channels aligned along the length.

A second aspect of the invention is a photocosmetic device for use on anarea of a patient's skin comprising a treatment head for use in closeproximity to the patient's skin, at least one electromagnetic radiationsource configured to project radiation through the treatment head ontothe area of skin, and a first mechanism coupled to the treatment headand configured to project a first substance onto the patient's skin. Theelectromagnetic radiation source may be positioned within the treatmenthead. The device may include an optical system to transmit radiation tothe area of skin, the optical system having a surface configured tocontact the patient's skin. The device may further comprise a coolingsurface thermally coupled to the at least one source and said surface;and second mechanism to project a phase change substance onto thecooling surface, wherein the first mechanism is configured to use a gasformed by the phase change of the second substance to drive the firstsubstance onto the patient's skin. The device may further comprising acooling surface thermally coupled to the source and said surface, and asecond mechanism configured to project a portion of the first substanceonto the cooling surface.

The first substance may be a liquid and the portion of the firstsubstance projected onto the skin is a gas resulting from a phase changeof the first substance. Alternatively, the first substance is a solidand the portion of the first substance projected onto the skin is aliquid resulting from a phase change of the first substance. In yetanother alternative, the first substance is a solid and the portion ofthe first substance projected onto the skin is a gas resulting from aphase change of the first substance.

The first substance may be a liquid, and the liquid may be a lotion.Alternatively, the first substance may be a gas, and the gas may becooled air. The second substance may comprise a plurality of components.The cooling surface may be a surface of a thermally conductive electrodeproviding power to the source. The cooling surface may be a surface of athermally conductive heat sink that is thermally coupled to the source.Optionally, the source is one of a diode laser bar, light emitting diodeand lamp.

A third aspect of the invention is a device for use on an area of apatient's skin comprising a treatment head for use in close proximity tothe patient's skin, at least one electromagnetic radiation sourcepositioned in the treatment head and configured to projectelectromagnetic radiation onto the area of skin, a cooling surfacethermally coupled to the at least one source of electromagneticradiation and including at least one channel therethrough, and amechanism to project a substance onto the cooling surface, and into theat least one channel.

The substance may be a liquid or a gas.

A fourth aspect of the invention is a device for use on an area of apatient's skin comprising at least one electromagnetic radiation sourceconfigured to project radiation onto the area of skin, a cooling surfacethermally coupled to the at least one source, and a solid mass thermallycoupled to the cooling surface, the solid mass changing phase inresponse to heat absorbed from the cooling surface.

In some embodiments the solid mass is ice or may be dry ice. The devicemay further comprise a mechanism to bring the solid mass into contactwith the cooling surface. The device may further comprise a treatmenthead, wherein the source is positioned within the treatment head. Thesource may be one of a diode laser bar, light emitting diode and lamp.

The cooling surface is a surface of a thermally conductive electrodeproviding power to the source or a thermally conductive heat sink thatis thermally coupled to the source.

A fifth aspect of the invention is a device for use on an area of apatient's skin comprising at least one electromagnetic radiation sourceconfigured to project electromagnetic radiation onto the area of skin, acooling surface thermally coupled to the at least one source, a solidmass thermally coupled to the cooling surface, at least a portion of themass becoming a liquid in response to absorption of heat from thecooling surface, and an exhaust vent configured to receive a portion ofthe liquid and project the portion of the liquid onto the patient'sskin.

The device may further comprise a mechanism for combining the liquidwith a chemical substance and directing the liquid and chemicalcombination onto the patient's skin.

A sixth aspect of the invention is a device for use on an area of apatient's skin comprising at least one electromagnetic radiation sourceconfigured to project electromagnetic radiation onto the area of skin, acooling surface thermally coupled to the at least one source, and areaction chamber thermally coupled to the cooling surface and containingat least a first chemical compound and a second chemical compound, thefirst and second chemical compounds selected to provide an endothermicreaction within the reaction chamber.

The cooling surface may be a surface of a thermally conductive electrodeproviding power to the source, or the cooling surface may be a surfaceof a thermally conductive heat sink that is thermally coupled to thesource.

A seventh aspect of the invention is a device for use on an area of apatient's skin comprising a treatment head for use in close proximity tothe patient's skin, at least one source of electromagnetic radiationpositioned in the treatment head and configured to projectelectromagnetic radiation onto the area of skin, and a cooling surfacethermally coupled to the at least one source of electromagneticradiation, the cooling surface having a channel therethrough to allow alow-boiling point liquid to flow onto a surface of the cooling surface.

The device may further comprise a valve connected to the channel tocontrol the evaporation of the low-boiling point liquid. The device mayalso further comprise a heat sensor to produce a signal indicative ofthe temperature of the area of skin, and a controller to receive thesignal from the heat sensor and control the valve in response to thesignal. The device may have a pressure source is coupled to the channelto control the boiling of the low-boiling point liquid. The source isone of a laser diode bar, light emitting diode and lamp.

The eighth aspect of the invention is a device for use on an area of apatient's skin comprising a treatment head for use in close proximity tothe patient's skin, at least one electromagnetic radiation sourcepositioned in the treatment head and configured to project radiationonto the area of skin, a heat spreader thermally coupled to the at leastone source, and a cooling surface thermally coupled to the heatspreader. The source may be one of a diode laser bar, light emittingdiode and lamp. The cooling surface may be a surface of a thermallyconductive electrode providing power to the source, or may be a surfaceof a thermally conductive heat sink that is thermally coupled to thesource.

A ninth aspect of the invention is a cooling system for cooling a heatgenerating device a cooling surface thermally coupled to the heatgenerating device, and a nozzle configured to project a high pressureliquid, the liquid forming a flowing liquid on the cooling surface. Thehigh pressure liquid may be projected such that the liquid forms astream of liquid the entire distance between the nozzle and the coolingsurface. The cooling surface may be textured. Optionally the coolingsystem may further comprise a cooling chamber to redirect the liquid tothe cooling surface. The cooling chamber may include sidewalls and acover. While many of the embodiments are described with reference toperforming photocosmetic treatments in a non-medical environment, it isto be understood that the benefits of aspects of this invention apply tomedical devices as well as non-medical devices, and the inventionapplies to either without limitation.

BRIEF DESCRIPTION OF THE DRAWINGS

Illustrative, non-limiting embodiments of the present invention will bedescribed by way of example with reference to the accompanying drawings,in which the same reference numeral is for the common elements in thevarious figures, and in which:

FIG. 1 is a schematic illustration of some basic elements of aphotocosmetic device according to some aspects of the present invention;

FIG. 2A is a side view of one example of a radiation system according tosome aspects of the present invention for use in performing aphotocosmetic procedure on an area of a patient's skin;

FIG. 2B is a schematic top view of an irradiated area of a patient'sskin taken along lines 2B-2B′ of FIG. 2A;

FIG. 3 is a side view of an example of a radiation system that iscapable of forming two areas of radiation on an area of a patient'sskin;

FIG. 4 is a top view of one example of a system appropriate forformation of islands of treatment;

FIG. 5 is a schematic cross-sectional side view of one embodiment of ahead according to aspects of the present invention;

FIG. 6A is a cross-sectional side view one example of one embodiment ofa cooling system that uses evaporative cooling;

FIG. 6B is a cross-sectional side view of another embodiment of acooling system utilizing a cooling liquid;

FIG. 6C is a schematic of another embodiment of a cooling systemutilizing a cooling liquid and having a cooling chamber;

FIG. 6D is a cross-sectional side view of an embodiment a head utilizinga cooling liquid in which the exhaust vent is separated from the portthrough which cooling liquid enters chamber;

FIG. 7 is a cross-sectional side view of an embodiment of a coolingsystem having channels;

FIG. 8 is a cross-sectional side view of another embodiment of a headutilizing evaporative cooling of a liquid;

FIG. 9 is a cross-sectional side view of an embodiment of a coolingsystem using a solid phase-change material according to aspects of thepresent invention;

FIG. 10 is a cross-sectional side view of an embodiment of a coolingsystem using an endothermic chemical reaction for cooling;

FIG. 11 is a cross-sectional side view of an embodiment of a devicehaving an exhaust vent to cool a patient's skin;

FIG. 12A is a side view of one example of an embodiment of asingle-element optical system appropriate for use with photocosmeticdevices according to some aspects of the present invention;

FIG. 12B is a ray trace of one example of an embodiment of an opticalsystem as illustrated in FIG. 12A;

FIG. 13A is a side view of one example of an embodiment of a two-elementcylindrical optical system appropriate for use with photocosmeticdevices according to some aspects of the present invention;

FIG. 13B is a ray trace of one example of an embodiment of an opticalsystem as illustrated in FIG. 13A;

FIG. 14A is a side view of another example of an embodiment of atwo-element cylindrical optical system appropriate for use withphotocosmetic devices according to some aspects of the presentinvention;

FIG. 14B is a ray trace of one example of an embodiment of an opticalsystem as illustrated in FIG. 14A;

FIG. 15A is a side view of another example of an embodiment of atwo-element cylindrical optical system appropriate for use withphotocosmetic devices according to some aspects of the presentinvention;

FIG. 15B is a ray trace of one example of an embodiment of an opticalsystem as illustrated in FIG. 15 A;

FIG. 16A is a schematic illustration of an exemplary embodiment of ahead for performing photocosmetic procedures;

FIG. 16B is a schematic illustration of an exemplary embodiment of ahead for performing photocosmetic procedures that also provides thecapability to perform muscle stimulation during a photocosmeticprocedure;

FIG. 17A is a schematic of one example of one embodiment of an apparatusaccording to some aspects of the invention, which optically determinescontact between an optical element and the surface of a patient's skin;

FIG. 17B is a schematic of one example of one embodiment of an apparatusaccording to some aspects of the invention, which optically determinescontact between an optical element and the surface of a patient's skin;

FIG. 17C is a schematic of one example of one embodiment of an apparatusaccording to some aspects of the invention, which electricallydetermines contact between an optical element and the surface of apatient's skin;

FIG. 18A is a cutaway side view of one embodiment of a handpiece havinga motion sensor;

FIG. 18B is a schematic of one example of an embodiment of a motionsensor system;

FIG. 19 is a schematic of another example of an apparatus having anoptical motion sensor;

FIG. 20 is a schematic of one example of one embodiment of a handpieceillustrating some aspects of a self-contained photocosmetic deviceaccording to the present invention;

FIG. 21 is a schematic of one example of an embodiment of a handpiecedocking station for docking a self-contained photocosmetic device;

FIG. 22 is a schematic of one example of one embodiment of a handpiecehaving a detachable head;

FIG. 23 is a schematic illustrating a modular handpiece having one ormore components suitable for user-replacement;

FIG. 24 is a schematic illustrating a modular optical assembly havingone or more components suitable for user-replacement;

FIG. 25 is a schematic of one example of a photocosmetic deviceillustrating some aspects of the present invention;

FIG. 26A is a schematic of one example of a photocosmetic headillustrating aspects of the present invention directed to treating acurved area of skin;

FIG. 26B is a schematic of one embodiment of two transmission systems ofa head to treat a curved surface;

FIG. 27 is a schematic illustrating an embodiment of some aspects ofhandpiece 2700 according to the present invention; and

FIG. 28 is a schematic illustration of one embodiment of a photocosmeticdevice according to at least some aspects of the present invention.

DETAILED DESCRIPTION OF THE INVENTION

FIG. 1 is a schematic illustration of some basic elements of aphotocosmetic device 100 according to some aspects of the presentinvention. Area 110 is an area of a patient's skin on which a selectedphotocosmetic treatment is to be performed. Area of skin 110 has a basallayer 140 in between an epidermal layer 120 and a dermal layer 130.Typically, photocosmetic treatments involve treating a target arealocated within epidermal layer 120 or dermal layer 130. For example, inthe case of hair removal, it may be desirable to heat a bulb 150 of ahair follicle 160. Alternatively, only a portion of bulb 150 may beheated, for example, the basement membrane 152 between the papilla andthe follicle.

In some embodiments of the present invention, the major sub-systems ofdevice 100 include a handpiece 170, a base unit 120 and cord 126 tocouple handpiece 170 to base unit 120. Base unit 120 may include a powersupply 124 to power control electronics 122 and electromagneticradiation (EMR) source 125. Power supply 124 can be coupled to handpiece170 via cord 126. Cord 126 is preferably lightweight and flexible.Alternatively, as described with reference to FIG. 21 below, cord 126may be omitted and base unit 120 may be used as a charging station for arechargeable power source (e.g., batteries or capacitors) located inhandpiece 170. In some embodiments, base unit 120 can be completelyeliminated by including a rechargeable power source and an AC adapter inthe handpiece 170.

Handpiece 170 includes a treatment head 180 (also referred to simply asa head) configured to be in contact with a patient's skin, and a handle190 that may be grasped by an operator to move head 180 in any directionacross the patients skin. For example, head 180 may be pushed across theskin in a forward direction 105 or pulled across the skin in a backwarddirection 106. Typically, during a given stroke, contact will bemaintained between head 180 and the patient's skin 110 while head 180 ismoved. Handpiece 170 may be mechanically driven or hand-scanned acrossthe skin surface of area 110. Firm contact between head 180 and skin 110is preferable to ensure good thermal and optical contact. As describedin greater detail below, in some embodiments of the present invention,head 180 and/or area of skin 110 are cooled by a passive or activecooling apparatus to prevent damage to the head and reduce theoccurrence of skin damage (e.g., wounds).

In an exemplary embodiment, source 125 is located in handpiece 170, forexample in head 180. Alternatively, source 125 is located in base unit120 and connected to head 180 via an optical fiber 128. Optical fiber128 may extend through handle 190, or may be otherwise connected to head180 for the purpose of delivering light to the patient's skin.

In some embodiments, controls 122 receive information from head 180 overlines 132, for example information relating to contact of head 180 withskin 110, the rate of movement of head 180 over the patient's skin,and/or skin temperature. Controls 122 may transmit control signals tohead 180 over lines 132. Lines 132 may be part of a cable that is alsoconnected to head 180 through handle 190 or may be otherwise connectedto the head. Controls 122 may also generate outputs to control theoperation of source 125 and may also receive information from thesource. Controls 122 may also control a selected output device 119, forexample an audio output device (e.g., buzzer), optical output device, asensory output device (e.g., vibrator), or other feedback control to anoperator. Depending on operator preference, other commonly used outputdevices may also be used. In some embodiments, output device 119 islocated within handpiece 170.

FIG. 2A is a side view of one example of an illumination system 200according to some aspects of the present invention for use in performinga photocosmetic procedure on an area of a patient's skin 110. FIG. 2B isa schematic top view of an irradiated area of a patient's skin 110 takenalong lines 2B-2B′ of FIG. 2A. In an exemplary embodiment of theinvention, system 200, including an EMR source 204, is located in thehead of a photocosmetic device (e.g., head 180 in FIG. 1) such that theEMR source is located proximate the skin surface 110.

Depending on the treatment to be performed, source 204 may be configuredto emit at a single wavelength, multiple wavelengths, or in a wavelengthband. Source 204 may be a coherent light source, for example a ruby,alexandrite or other solid state laser, gas laser, diode laser bar, orother suitable laser light source. Alternatively source 204 may be anincoherent light source for example, an LED, arc lamp, flashlamp,fluorescent lamp, halogen lamp, halide lamp or other suitable lamp.

An optical system 206, comprised of a plurality of optical elements,includes a surface 207 for transmitting radiation from an EMR source 204and for contacting the patient's skin 110. Further details of opticalsystem 206, are given below with reference to FIGS. 12-16. The phrase“optical system” is used herein to refer to a system for transmittingany type of optical radiation suitable for performing photocosmeticprocedures.

In some embodiments, source 204 has an extended dimension in thex-direction (e.g., the light source is substantially linear). One ofordinary skill would understand that a plurality of point sources may becombined to form a substantially linear source. Additionally, relativelysmall linear sources may be combined to form a single, longer continuouslinear source, or a longer linear source having one or morediscontinuities. For example, source 204 may be a diode laser bar havinga 1 cm long emission line and a few micron line width; optionally source204 may include two or three bars placed in a line along the x-directionto create a 2 cm or 3 cm long emission line.

Alternatively, linear sources may be placed adjacent to one another inthe y-direction to form a source having an increased line width. System200 may include one or more additional sources 205, similarly ordifferently configured than the one or more sources 204. In embodimentshaving two sources, source 204 and source 205 may emit at the same ordifferent wavelength ranges.

In embodiments having multiple EMR sources 204, 205, it may be desirableto activate only selected sources for a given treatment. For example, inembodiments having sources emitting at different wavelengths, forcertain applications, for example, hair removal, it may be preferable toonly activate a selected one or more sources and for certain otherapplications, for example, acne treatment or skin rejuvenation, toactivate a selected one or more other sources. While sources arediscussed as emitting radiation at a wavelength, one of ordinary skillwould understand that any radiation source produces light over a finiterange of wavelengths, accordingly a specified wavelength may be a partof a broader range.

Radiation source 204 may be a pulsed or continuous wave (CW) source. Forapplications that require coverage of large areas such as hair removal,CW diode laser bars may be preferable. A method of utilizing continuouswave (CW) light sources for the treatment of various dermatologicdisorders is described in U.S. Pat. No. 6,273,884 B1 entitled “Methodsand Apparatus for Dermatology Treatment,” to Altshuler, et al., thesubstance of which is hereby incorporated by reference. Some aspects ofthat patent teach the use of a CW light source in combination with acontact optical delivery system that can be either hand scanned ormechanically driven across the skin surface to create a precisetemperature rise in the targeted biological structures (i.e., usingcontinuous contact scanning (CCS)).

Most commercial diode laser bars exhibit lifetimes of >5000 hours, butapplication according to the present invention may only require 10-100hour lifetimes. Accordingly, in some embodiments of the presentinvention, a source 204 may be overdriven with current to increaseradiation output, thus causing the diode laser to operate at a highertemperature, and thereby sacrificing lifetime.

Diode laser bars appropriate for use with the present invention includediode laser bars emitting at wavelengths of 790-980 nm or other suitablewavelengths. Examples of sources of diode laser bars appropriate for usewith aspects of the present invention include Coherent Inc. of SantaClara, Calif., or Spectra Physics of Mountain View, Calif. The aboveexamples of sources 204, 205 are exemplary and it should be understoodthat aspects of the present invention include devices and apparatususing any appropriate EMR source currently available oryet-to-be-developed.

For some embodiments of the present invention, for example thoserequiring either low power or for treatment of small areas of apatient's skin, LEDs may be used as light sources 204, 205. LEDs areavailable in a wide range of emission wavelengths. Similar to the diodelaser sources discussed above, multiple LEDs emitting at differentwavelengths could be used in a single optical system. Typical lifetimesfor LEDs are in the 50,000-hour range; similar to laser diodes, it maybe possible to overdrive an LED and sacrifice lifetime to generatehigher optical power. For applications that require high power density,a reflective concentrator (e.g., a parabolic reflector) could be used todecrease the spot size at the skin surface.

Broadband sources (e.g., low-power halogen lamps, arc lamps and halidelamps) are another type of light source that could be used as sources204, 205. One or more optical filters 240 and 242 can be used to providea wavelength band of interest for a given application. Multiple lampscan be combined to produce high power, and, similar to the case of LEDs,a concentrator could be used to decrease the spot size at the skinsurface. In some embodiments, several different types of light sourcescan be incorporated into a photocosmetic device (e.g., device 100 ofFIG. 1).

In some embodiments of system 200, a beam splitter 230 splits radiationfrom source 204 to form a first portion of EMR and a second portion ofEMR. The first portion and second portion may be filtered by filters 240and 242 respectively. After filtering, the portions may have the same ordifferent wavelength ranges. The functions of the first and secondportions may be the same or different. For example, the function of thesecond portion of EMR may be to preheat the patient's skin 110 inpreparation for treatment by the first portion of EMR. Alternatively,both the first portion of EMR and the second portion of EMR may providetreatment.

Referring to FIG. 2B, in some embodiments, optical system 206 (visiblein FIG. 2A) is configured to form a first area of radiation 210 along afirst axis 211 on the patient's skin 110. First area of radiation 210 isformed from at least a first portion of electromagnetic radiation fromsource 204 (visible in FIG. 2A). In some embodiments, a second area ofradiation 220 along a second axis 221 is formed on the patient's skin110. Second area of radiation 220 may be formed from a second portion ofelectromagnetic radiation from the radiation source 204; alternativelysecond area of radiation 220 may be formed from light from secondradiation source 205 (visible in FIG. 2A).

In some aspects of the present invention, the first axis 211 and secondaxes 221 are parallel; however in other embodiments, the axes 211, 221are not parallel. System 206 may be configured to form the first area210 a selected distance from the second area 220, or may be configuredsuch that the first portion of radiation overlaps at least a part of thesecond portion of radiation. Optionally, system 206 is configured toform (e.g., focus or collimate) the first portion and second portionsubstantially as lines. Optical system 200 may be configured to produceone or more lines of light at the skin surface, each having a length of1-300 mm and a width of 0.1-10 mm. Astigmatism of the beam can be in therange 0.01-0.5. The term “astigmatism” is herein defined to mean theratio of beam width to the beam length. Also, optionally, system 206 maybe configured to form one or more additional areas of radiation alongadditional axes (not shown) on the patient's skin 110, the additionalareas of radiation formed from corresponding additional portions ofelectromagnetic radiation from the radiation source 204 or 205, orradiation from one or more additional radiation sources.

FIG. 3 is a side view of another example of an illumination system 300for use in performing photocosmetic procedures, that is capable offorming two areas of radiation 311, 316 on an area of a patient's skin110. In system 300, two optical systems 310, 315, instead of a singleoptical system 206 (FIG. 2), each generate a corresponding area ofradiation 311, 316 (e.g., areas of radiation 210, 220). The radiationused to generate the lines may be from two sources 304, 305 or a singledivided source as described above with reference to FIG. 2.

FIG. 4 is a top view of one example of an illumination system 400appropriate for formation of islands of treatment. System 400 includes aplurality of sources 410 (e.g., a conventional laser diode emitting aline or circular spot of illumination), each having a correspondingoptical system 415 to direct light onto an area of skin. The illustratedsystem may be used to create a square (or arbitrarily shaped) matrix offocal spots having islands of treatment within the area of skin. Theterm “island” as used here is defined to mean an area of specifiedtreatment separated from other areas of the specified treatment, suchthat areas between two or more areas receive radiation in an amountbelow that necessary to achieve the specified treatment. Islands ofillumination are discussed in greater detail in U.S. Provisional PatentApplication 10/033,302, filed Dec. 27, 2001, by Anderson, entitled“Method and Apparatus for EMR Treatment” the substance of which ishereby incorporated by reference.

For embodiments of photocosmetic devices according to the presentinvention that utilize high-power sources, management of waste heat fromthe sources is important for avoiding wounds and other injuries to theconsumer. For example, in the case of a photocosmetic device thatincludes diode laser bars in the handpiece, up to 60% of the electricalenergy may be dissipated in non-optical waste heat. In addition to theremoval of heat to avoid wounds, removal of heat may be important toprevent the source from overheating and shortening the lifetime of thesource.

FIG. 5 is a schematic cross-sectional side view of one embodiment of ahead 500 according to aspects of the present invention. Head 500includes an illumination system including an EMR source (e.g., diodelaser bar 510) and an optical system 520. Head 500 may be located in ahousing to protect the optical components and to protect the operator ofa photocosmetic device; the housing is omitted to avoid obfuscation. InFIG. 5, a diode laser bar 510 operates as the source of electromagneticradiation (e.g., source 204 in FIG. 2) and may be used to form one ormore areas of radiation (e.g., 210, 220 in FIG. 2). Diode laser bar 510is located between positive electrode 515 and negative electrode 516.Electrodes 515, 516 provide electrical power to diode laser bar 510, andmay be made of any suitable material having good electricalconductivity. In some embodiments, electrodes 515, 516 are in thermalcontact with diode laser bar 510, and have good thermal conductivity totransfer waste heat away from diode laser bar 510. For example,electrodes 515 and 516 may be made of aluminum or copper.

Optionally, waste heat from diode laser bar 510 may be transferred viaelectrodes 515 and 516 to a heat sink 530. Heat sink 530 may be made ofany material having good thermal conductivity to transfer waste heataway from diode bar 510. For example, heat sink 530 may be made ofaluminum or copper. Heat sink 530 can be cooled by any appropriate,known method of cooling including a stream of air. Optionally, coolingmay be enhanced by adding fins (not shown) to heat sink 530.Alternatively, heat sink 530 may be cooled by one or more of the heatremoval methods discussed below with reference to FIGS. 6-11. Alsooptionally, a heat spreader 522 may be located between electrodes 515,516 and heatsink 530. Heat spreader 522 is thermally coupled toelectrodes 515, 516 and heat sink 530. Heat spreader 522 may be made ofany suitable material having good thermal conductivity; preferably heatspreader 522 is electrically insulative. Diamond and carbon fiber aretwo examples of materials suitable for use as heat spreaders.

In some embodiments, electrodes 515, 516 are configured to be heat sinksto conduct waste heat away from diode laser bar 510. Accordingly, heatsink 530 and heat spreader 522 may be omitted. In such embodiments,electrodes 515 and 516 can be made of any materially exhibiting goodthermal and electrical conductivity. Optionally, one or more thermalsensors 524 (e.g. a thermocouple, a thermistor) may be used to monitor atemperature indicative of a patient's skin (e.g., the temperature at theinterface of an optical system 520 and electrode 516) for use in acooling system as described below.

Diode laser bar 510 may be secured to electrodes 515 and 516 using anymethod capable of maintaining good electrical contact between bar 510and electrodes 515,516. In embodiments where transfer of waste heat isdesired, any suitable method of achieving good thermal and electricalcontact may be used. In one embodiment, diode laser bar 510 is clampedbetween the two electrodes 515 and 516. A spring or other suitabledevice may be used to clamp diode laser bar 510 firmly betweenelectrodes 515, 516. In another embodiment, diode laser bar 510 may alsobe glued in place with thermal/electrical conductive epoxy. In anotherembodiment, diode laser bar 510 is soldered in place with alow-temperature solder (In or Au/Sn solder, etc.). Automated solderingmay be achieved using an indium preform placed between diode laser bar510 and electrodes 515 and 516, and applying heat using a die bonder toheat, compress, and then cool the solder and diode bar. Optionally, aspacer 525, made out of a material with high thermal and low electricalconductivity such as BeO, may be included to provide electricalinsulation between the electrodes 515 and 516.

According to some aspects of the present invention, optical system 520couples light from diode laser bar 510 to a patient's skin. Opticalsystem 520 may be separated from diode laser bar 510 by an air gap 511.Exemplary optical systems 520 are described in greater detail below withreference to FIGS. 12-15. In embodiments according some aspects of thepresent invention, optical system 520 is configured to contact an areaof a patient's skin, and the optical surface 521 is cooled to providecooling to the patient's skin.

In some embodiments, cooling of diode laser bar 510 and optical system520 are achieved using a single cooling system. For example, electrodes515, 516 may be thermally coupled to optical system 520 along dimensionsA; accordingly, both diode laser bar 510 and optical system 520 may becooled by cooling the electrodes 515, 516 directly or via cooling of aheat sink 530 that is thermally coupled to electrodes 515, 516.Dimensions A are typically both between roughly 1 and 10 mm. Furtherdetail regarding simultaneous cooling of an optical source and anoptical system are given in U.S. application Ser. No. 09/473,910, filedDec. 28, 1999, the substance of which is hereby incorporated byreference.

Contact cooling of the skin may be used to protect a patient's epidermisduring delivery of high-fluence radiation to the skin, for example atwavelengths where melanin exhibits significant absorption. In someembodiments of head 500, optical system 520 includes a sapphire elementconfigured to contact a patient's skin due to its good opticaltransmissivity and thermal conductivity. As described above, opticalsystem 520 may be cooled to remove heat from the sapphire element duringtreatment. Optionally, prior to treatment with the photocosmetic device,a lotion that is transparent at the operative wavelength(s) may beapplied on the skin. Preferably, the location is thermally conductive toenhance heat removal from the skin through optical surface 521.Preferably, the lotion also facilitates the gliding motion of theoptical system 520 over the skin surface and has a refractive indexmatch between contact surface 520 and the skin 110 to provide efficientoptical coupling of the radiation into the skin.

The lotion may also be used to show which skin areas have been treatedby choosing a lotion with optical properties (e.g., color orreflectance) that are altered in response to irradiation by an EMRsource (e.g., laser diode 510). For example, if the lotion is initiallya given color, after irradiation it would become transparent (or adifferent color). The ability to distinguish treated from untreatedareas is particularly important for treatments such as hair removal thatare performed over a large surface area.

FIG. 5 also illustrates one embodiment of a system for cooling diode bar510 and optical system 520 via heat sink 530. In FIG. 5, a heatabsorbitive liquid flows through a thermally conductive conduit 540 thatis thermally coupled to heatsink 530. For example, in one embodiment,water is used as the liquid. Optionally water may be provided byattaching a source of cold water, such as tap water; referring to FIG.1, water may be provided through a handle 190 having suitable plumbing.Alternatively, a closed-circuit cooling loop having a heat exchanger(not shown) to remove heat from the liquid; the heat exchanger may belocated in handle 190 or base unit 120.

Referring again to FIG. 5, conduit 540 covers at least a portion of oneor more surfaces, for example, surface 542 of heat sink 530. A singleplanar conduit may cover the entirety of one or more surfaces of heatsink 530. Alternatively, a plurality of conduits, each covering aportion of a surface heatsink 530, may be used. Alternatively, one ormore conduits 540 may cover at least a portion of electrodes 515, 516.Since cooling may be applied to either heat sink 530, directly toelectrodes 515, 516, a surface of a heatsink (e.g., surface 542), asurface of an electrode, or any other appropriate surface from whichheat is to be removed shall hereinafter be referred to as a “coolingsurface.” While a cooling surface is illustrated as an external surface,it is to be understood that a cooling surface may be an internalsurface, such as a surface exposed to a conduit through a heat sink oran electrode.

FIG. 6A is a cross-sectional side view one example of one embodiment ofa cooling system 600 that uses evaporative cooling. In FIG. 6, a phasechange liquid is sprayed from one or more spray jets 610 and 620 ontothe cooling surface 623. The liquid can be any suitable evaporativeliquid, such that the liquid evaporates in response to heat absorbedfrom the cooling surface. In some embodiments, the liquid is alow-temperature boiling-point liquid, directed on the heat sink suchthat as the liquid boils in response to heat absorbed from the coolingsurface 623. In some embodiments, the liquid is tetrafluoroethane(boiling point −26° C.), CO₂ (boiling point −78° C.) although any othersuitable liquids (e.g., freon or liquid nitrogen) could also be used. Insome embodiments, the liquid is atomized by spray jets 610 and 620.

Optionally, the liquid can be contained in a container 625 located inthe base unit or handle. Preferably, container 625 is convenientlyaccessible by a user so as to be user-replaceable A conduit 626 is usedto transport the liquid to spray jets 610 and 620. The amount of coolantflow is regulated by valve 627, which can be controlled manually orelectrically using information regarding the amount of heat present in asystem (e.g., system 500 of FIG. 5). For example, a sensor (e.g., sensor524 in FIG. 5) can be used to control a feedback-controlled solenoid invalve 627. Optionally, each spray jet 610 and 620 can be a combinationvalve and spray jet eliminating the need for a separate valve 627.

Optionally, the cooling surface 623 from which evaporation occurs can betextured to increase the surface area from which the liquid can beevaporated. Although triangular texturing 615 of the evaporative surfaceis shown, any shape suitable for increasing surface area may beimplemented. The illustrated triangular texturing 615 may be a part of alinear grooves pattern, a cross-sectional view of a concentric circulargroove pattern or any other appropriate groove pattern. Other texturingincludes a plurality of projections (e.g., semispheres, cylinders, orpyramids projecting from the cooling surface). Optionally, a collar 630may be used to surround spray jets 610, 620 and heat sink 530 to containthe spray.

A phase change liquid may also be used to cool the electronics 644 usedto power and/or control a photocosmetic device. In particular, powerfield effect transistors (FETs) used to control the power of aphotocosmetic device generate a large amount of heat. Conventionally,power FETs have been cooled using a relatively large heat sink, and afan to remove heat. Such systems tend to be large and heavy. Coolingsystems according to the present invention provide an alternative methodof cooling.

Optionally, a portion of the phase change liquid conduit 626 thatprovides liquid to remove heat generated by the EMR source may beconfigured to direct a portion of the phase change liquid to the sprayjet 640. Spray jet 640 directs a portion of the phase change liquid ontoa cooling surface (e.g., a surface of a heat sink 642). A heat sensor646 (e.g., a thermistor) may be used to control the amount of liquidprojected onto cooling surface, for example, by controlling a valve 650.

FIG. 6B is a schematic of another embodiment of a cooling system 650 foruse in a head utilizing a flowing, cooling liquid 605. In FIG. 6B, ahigh-pressure liquid is maintained in a container 655 (e.g.,tetrafluoroethane under 1 to 5 atmospheres of pressure) and projectedthrough a nozzle 660 onto a cooling surface 665. The projected liquid607 from nozzle 660 may be in the form of droplets or stream of liquid.In some embodiments, the liquid is projected as a stream to overcome thepoor aerodynamic properties (i.e., high drag) of droplets, thusimproving the heat removal properties of cooling system 650. Asdescribed above, cooling surface 665 may be any material that is a goodconductor of heat (e.g., copper or silver). Preferably, cooling surface665 is selected to have dimensions large enough such that the liquid 655evaporates from surface 665 rather than drips off said surface.

Projected liquid 607 from nozzle 660 is projected onto cooling surface665 to form a flowing liquid 605 on cooling surface 665. Nozzle 660 andcooling surface 665 may be selected such that the liquid 607 projectedfrom the nozzle 660 is a stream of liquid the entire distance betweenthe nozzle 660, and upon impinging surface 665 forms a flowing liquid atcooling surface 665. Alternatively, nozzle 660 and cooling surface 665may be selected such that the liquid 607 projected from nozzle 660 mayform a spray of droplets between nozzle 660 and cooling surface 665before aggregating to form a flowing liquid at cooling surface 665.Because liquid projected from nozzle 660 is under high pressure, theflowing liquid on the cooling surface 665 flows across the coolingsurface 665 at a relatively high speed V.

Forming a flowing liquid 605 on cooling surface 665 may be used toprovide increased heat removal from surface 665 compared to conventionalcooling system in which droplets (i.e., a non-flowing liquid) are formedon cooling surface 665. For example, the improved heat removal mayresult from the fact that droplets (as formed in a conventional system)are not formed in sufficient number or density to achieve and maintain aselected amount of heat removal.

FIG. 6C is a schematic of another embodiment of a cooling system 670 foruse in a head, utilizing a cooling liquid 655 and having a coolingchamber 684. Head 670 has sidewalls 675 and a cover 680 having a port682 for entry of the liquid 655 from nozzle 660. Sidewall 675 and cover680 form chamber 684. Port 682 may also serve as an exhaust vent forevaporated cooling liquid. As indicated by arrows 686, sidewalls 675 andcover 680 redirect the liquid 655 from cover 680 back to the coolingsurfaces 665. The sidewalls 675 are preferably selected to be thermallycoupled to the cooling surface 665 such that liquid contacting thesidewalls 675 may remove heat from the cooling surface 665. Optionally,the side walls 675 may be integrated with cooling surface 665 such thatliquid contacting the sidewall 675 may remove heat. In some embodiments,it may be preferable that cover 680 have poor thermal conductivity andpoor wetting characteristics for the cooling liquid to improve thelikelihood that the cooling liquid will reach the cooling surface 665.For example, in some embodiments, cover 680 is made of a polymer ororganic glass. Although chamber 684 is illustrated as having sidewallsand a cover forming an angle therebetween, the chamber may be formedhaving a continuous curvature.

Because port 682 operates as an exhaust vent from evaporated liquid 655,the area S of port 682 determines the pressure maintained within chamber684. In some embodiments, port 682 is selected to have an area S largeenough to prevent back pressure that slows the speed of the liquidprojected on the cooling surface 665; however, port 682 may be selectedto be small enough to allow the cover 680 to redirect a significantportion of liquid back to the cooling surface 665, and to maintainpressure in chamber 684 to keep the liquid from evaporating too quickly.For example, port area S may be approximately one hundred to two hundredtimes as large as the area s of nozzle 660. In some embodiments, thecooling liquid is selected to be a liquid that has an boilingtemperature (i.e., evaporation temperature) of less than −26 degreesCelsius for pressures less than or equal to atmospheric pressure.

FIG. 6D is a cross-sectional side view of an embodiment a laser head 690utilizing a cooling liquid in which the exhaust vent 692 is separatedfrom the port 694 through which cooling liquid enters chamber 696.Chamber 696 is bounded by a cooling surface 688, side walls 693, and acover 695. Cooling surface 688 is thermally coupled to source 525, andoptical system 520 via coupling plates (described in greater detailbelow). A cooling liquid from nozzle 698 is projected onto texturedcooling surface 688. A portion of the cooling liquid which does notcontact cooling surface 688 directly is redirected by side walls 693 andcover 695 as indicated by arrows 686.

Optionally, cover 695 may be selected to have a resonant frequency toenhance its ability to redirect the liquid to cooling surface 688. Also,optionally a means to reduce the kinetic energy of the liquid (e.g.,propeller, not shown) may be placed between the nozzle 698 and thecooling surface 688 to cool the liquid.

FIG. 7 is a cross-sectional side view of an embodiment of a head 700 forcontacting skin surface 110. Head 700 has channels 730 and 731 in theelectrodes 515, 516). Evaporative cooling may occur along the bottomsurface of electrodes 515, 516 and along the surface of channels 730,731, thus increasing the cooling surface area of head 700. Preferably,the location of channels 730 and 731 is proximate diode laser bar 510.In one embodiment, channels 730, 731 are located along the length of thediode laser bar 510 (i.e., along direction-x). In some embodiments,channels 730, 731 are located proximate a spray jet 610 to receivespray. Channels 730 and 731 may have a rectangular cross section or anyother shape appropriate to improve cooling. For example, openings 740,742 may be flared to receive spray from spray jet 610. As an alternativeto a single channel extending along the length of the diode bar 510, aseries of channels may be placed on one or both sides of diode laser bar510 along the length of the diode laser bar.

FIG. 8 is a cross-sectional side view of another embodiment of a coolingsystem 800. In FIG. 8, a liquid is used to remove heat from coolingsurface 823 but the liquid is not used in spray form. In the illustratedexemplary embodiment, liquid flows out of reservoir 825 into a pluralityof channels 832 located within cooling surface 823. The length of eachof the plurality of channels 832 extends in the direction of the lengthof source 510. The liquid is brought into thermal contact or physicalcontact with cooling surface 823.

Optionally, the liquid may be a low-boiling point liquid that evaporatesin response to heat absorbed from cooling surface 823. A valve 833 maybe used to control the liquid evaporation; when significant cooling isdesired, valve 833 is opened and a pressure less than equilibrium isapplied to the liquid to facilitate evaporation. The pressure dropcauses the liquid to boil, which removes heat from cooling surface 823.Although channels 832 are illustrated as extending in a directionparallel to the length of light source 510, and the channels areillustrated as having rectangular cross sections, other shape ofchannels 832 aligned in one or more in various directions are possibleand are within the scope of the present aspect of the invention. Afeedback signal can be derived from a thermal sensor (e.g., sensor 524in FIG. 5) to control a solenoid in control valve 833.

FIG. 9 is a cross-sectional side view of another exemplary embodiment ofa head 900 for contacting a skin surface 110. Head 900 has a coolingsystem having a cooling surface 923 that is brought into physicalcontact with a solid mass (also referred to as a phase change solid). Atleast a portion of the solid mass 834 changes phase in response to heatabsorbed from cooling surface 923. The phase change may be from a solidto liquid, or a solid to a gas. In some embodiments, the solid has amelting temperature between approximately −10C and +30C; however, insome applications, materials undergoing a phase change outside thisrange, particularly below this range, may be utilized.

In some embodiments, the solid mass is conveniently located within adevice handpiece (e.g. handpiece 170 in FIG. 1) so as to be userreplaceable. In some embodiments, the solid mass is contained in aninsulating sleeve to avoid contact with user's hands, and/or to minimizemelting do to exposure to room temperature. In the illustratedembodiment, temperature control can be achieved by using a manually orelectrically controlled solenoid or a spring 835 to bring the solid massin and out of contact with cooling surface 923.

In one embodiment of the phase-change cooling system, the phase-changesolid is ice. In this embodiment, a user could keep one or more frozenice blocks in his/her freezer. When the user wanted to operate thephotocosmetic device, a frozen ice block could be inserted in thedevice. In another embodiment, dry ice, which has a significantly lowermelting point than water, could also be used to achieve greater coolingcapacity. It is to be understood that the ice block may contain water,or water with one or more additives to treat a user's skin.

In some embodiments, commercially available organic compounds (e.g.,paraffin wax-based materials, fatty acids, cross-linked polyethylenes)may be used as phase change solids. Examples of appropriate paraffin waxmaterials include RT25 produced by Rubitherm GmbH. RT25 has a meltingpoint of 27.7° C. In other embodiments, greases having melting points inthe 20-35° C. range may be used as the phase change solid. In anotherembodiment, Ga or a Ga alloy (e.g., Ga/In, Ga/In/Sn, or Ga/In/Sn/Zn),which is tailored to exhibit a melting point in the 15->50° C. range, isused as the solid mass. In a Ga/In alloy, the relatively high thermalconductivity of Ga (40.6 W/m*K) and In (81.6 W/m*K) would help to spreadthe waste heat throughout the alloy volume. A disposable phase-changecooler cartridge may be used to contain the phase-change solid; forexample, the phase change solid may be used either once and thendiscarded or may be rechargeable (i.e., resolidified one or more times).

FIG. 10 is an embodiment of a head 1000 having a cooling system in whichan endothermic chemical reactions is used for cooling. Examples ofappropriate reactions are ammonium nitrate (NH₄NO₃) or ammonium chloride(NH₄Cl) introduced into water causing an endothermic reaction. Forexample, if 200 ml of water is mixed with 200 g of ammonium nitrate, atemperature of approximately −5° C. can be achieved, thus allowingabsorption of a heat.

In FIG. 10, an endothermic reaction is contained within a reactionchamber 1050, and the reaction chamber is thermally coupled to coolingsurface 1023. In some embodiments, reaction chamber 1050 could becoupled to the cooling surface 1023 via a material having a good thermalconductivity. In some embodiments, the mechanism includes a thinmembrane 1051 separating a first chamber of water and another chamber ofammonium chloride. In some embodiments, membrane 1051 can be broken toinitiate the reaction and the reaction chamber could be a disposablecontainer. For example, the user could apply force to a flexible plasticreaction chamber to break a membrane and thereby produce a reservoir ofcold liquid prior to turning on the device. Alternatively, the membranemay be removed or otherwise manipulated according to any known means toallow contents of the first chamber and the second chamber to interact.

FIG. 11 is a cross-sectional side view of an embodiment of a device 1100having a conduit 1110 and an exhaust vent 1120. In FIG. 11, a liquid orgas entering exhaust vent 1120 is directed to an area of skin 1130 so asto pre or post cool the area of skin 1130 during treatment. For example,a portion of the same cooling liquid that is sprayed onto coolingsurface 530 or the gas resulting from the evaporation of the liquid mayenter conduit 1110 and be sprayed onto skin by vent 1120. The portion ofliquid may be condensed evaporate or simply excess liquid. If, asdescribed above, tap water was utilized for cooling (or an icephase-change cooler as described with reference to FIG. 9), it may bepossible to divert a portion of the water after the water was used tocool the cooling surface 530. In some embodiments, the pressure from agas resulting from a phase change cooling system may be used to drive alotion onto a patient's skin. Although the illustrated embodimentillustrates diverting a portion of the cooling liquid after it is usedto cool surface 530, in some embodiments a portion of the cooling liquidmay be directly projected onto the skin without being used to cool thecooling surface 530.

Optionally, one or more additives may be added to the liquid via conduit1112 (e.g., to form a cooling lotion) prior to spraying on the skin. Theadditives could be stored in a cartridge (not shown) in the handpiece orbase unit. In some embodiments, to achieve a “shower effect,” all of thewater exiting the heatsink could be exhausted onto the skin. As analternative to using the evaporative liquid, an alternative source ofgas, liquid or lotion (i.e., independent of the cooling system) could bestored in a cartridge in the handpiece or the base unit and dispensedwhile the handpiece is moved across the skin surface.

To avoid obfuscation, the following exemplary embodiments of opticalsystems for use with aspects of the present invention will be describedwith reference to a single electromagnetic radiation source; however asdescribed above, one or more sources may be used to form one or moreareas of radiation. In the exemplary optical systems described below,each of the surfaces having optical power has optical power along afirst axis (e.g., the y-axis) and zero optical power along an axisnormal to the first axis (i.e., the x-axis). That is, the lenses arecylindrical. Although the embodiments discussed below have planar orcylindrical curvatures, other refractive or diffractive optical designsare within the scope of the present invention.

FIG. 12A is a side view of one example of an embodiment of a singleelement optical system 1200 appropriate for use with photocosmeticdevices according to some aspects of the present invention. Opticalsystem 1200 includes an element 1210 for transmitting light from anelectromagnetic radiation source 1220 (e.g., a laser diode bar) to apatient's skin 110. Element 1210 has an input surface 1211 and an outputsurface 1212 configured to contact a patient's skin surface.

Source 1220 is closely coupled to input surface 1211 of the element 1210(e.g., 1 mm separation); close coupling enables a large fraction oflight along a highly divergent fast-axis of a laser diode source to betransmitted to a patient's skin. In some embodiments, input surface 1211has an antireflective (AR) coating.

As described above, element 1210 is made of a material substantiallytransparent at the operative wavelength, and preferably made of amaterial that is thermally conductive to remove heat from a treated skinsurface (e.g., sapphire). In some embodiments, the lateral sides 1213 ofelement 1210 are coated with a material reflective at the operativewavelength (e.g., copper, silver or gold). Additionally, the space 1221,between source 1220 and input surface 1211, may be surrounded with areflective material to increase the strength of light incident onsurface 1211.

In one embodiment, optical element 1210 is a sapphire plate (i.e.,surfaces 1211 and 1212 are planar, and have no optical power). Inanother embodiment of optical system 1200, optical surface 1212 has acylindrical curvature (as shown in FIG. 12) and is selected to convergelight incident on surface 1212. For example, in one embodiment, surface1212 has a radius of curvature of approximately 3 mm. This system can beused to treat skin structures that require high treatment fluence. Forexample, the lens system of FIG. 13 can be used to target stem cells ofhair follicle, sebaceous gland, infrainfundibulum, vascular tissue,tattoos, or collagen.

In some embodiments, lateral surfaces 1213 have a length L approximatelyin the range 5-50 mm, and a cross-sectional width (measured in thex-direction) and height (measured in the y-direction) are selected tocollect light from source 1220. For example, for a source comprised oftwo 1 cm diode laser bars close-coupled to element 1210, thecross-sectional width is selected to be 2 cm, and the cross-sectionalheight is 2 cm.

As illustrated, optical element 1210 transmits a portion of light fromsource 1220 directly to surface 1212 with no reflections on lateralsurfaces 1213 (e.g., exemplary ray 1230) and a portion of light fromsource 1220 is reflected from lateral surfaces 1213 prior to reachingsurface 1212 (e.g., exemplary ray 1232). An element, such as element1210, that directs a portion of light from source to surface using totalinternal reflection is also referred herein to as a “waveguide.”

Optionally, a tip reflector 1222 may be added to redirect lightscattered out of the skin back into the skin (referred to as photonrecycling). For wavelengths in the near-IR, between 40% and 80% of lightincident on the skin surface is scattered out of the skin; as one ofordinary skill would understand the amount of scattering is partiallydependant on skin pigmentation. By redirecting light scattered out ofthe skin back toward the skin using tip reflector 1222, the effectivefluence provided by system 1200 can be increased by more than a factorof two. In one embodiment, tip reflectors 1222 extend a total of 3 mmfrom the upper lateral surface and lower lateral surface of element1210. In some embodiments, tip reflectors 1222 have a copper, gold orsilver coating to reflect light back toward the skin.

A reflective coating may be applied to any non-transmissive surfaces ofthe device that are exposed to the reflected/scattered light from theskin. As one of ordinary skill in the art would understand, the locationand efficacy of these surfaces is dependent on the chosen focusinggeometry and placement of the light source(s). Photon recycling isdiscussed further in U.S. application Ser. No. 09/634,981, filed Aug. 9,2000, entitled “Heads for Dermatology Treatment,” by Altshuler, et al.,and application Ser. No. 09/268,433, filed Mar. 12, 1999; the substanceof both is hereby incorporated by reference. FIG. 12B is a ray trace ofone example of an embodiment of such an optical system 1200 having asource 1220 and an element 1210 as illustrated in FIG. 12A.

FIG. 13 is a side view of one example of an embodiment of a two-elementcylindrical optical system 1300 appropriate for use with photocosmeticdevices according to some aspects of the present invention, in which acollimator 1310 is used in conjunction with element 1210. In FIG. 13, afast-axis collimator 1310 is very closely coupled to optical source 1220(e.g., 0.09 mm). In one embodiment, collimator 1310 has a length 1.5 mm,a planar input surface 1311, and an output surface 1312 having acurvature to collimate the output of collimator 1310. Element 1210 islocated 0.1 mm from output surface 1312. Collimator 1310 produces a beamof radiation that is substantially collimated in the y-dimension atoutput surface 1312. For example, collimator 1310 may be a lens modulenumber S-TIH53 produced by Limo Gmbh of Dortmund, Germany.

The collimated beam is projected onto input surface 1211 of opticalelement 1210. As described above, element 1210 may be a plate or may beweakly converging (e.g., output surface 1212 may have a radius ofcurvature equal to 3 mm) to compensate for scattering in the skin. Thissystem can be used to treat skin structures that require high treatmentfluence. For example, the lens system of FIG. 13 can be used to targetstem cells of hair follicle, sebaceous gland, infrainfundibulum,vascular, tattoo, or collagen. FIG. 13B is a ray trace of one example ofan embodiment of such an optical system 1300 having a source 1220 and acollimator 1310 and an element 1210 as illustrated in FIG. 13A.

FIG. 14A is a side view of another example of an embodiment of atwo-element cylindrical optical system 1400 appropriate for use withphotocosmetic devices according to some aspects of the presentinvention. In optical system 1400, the fast-axis collimator 1310 of FIG.13 is used in conjunction with an element 1420 located 0.1 mm fromsurface 1312 of collimator 1310 to project light from source 1220.Element 1420 has an input surface 1421 with a curvature of 1 mm, aplanar output surface 1422, and a length of 1 mm. System 1400 focuseslight at approximately 1 mm from surface 1422 (i.e., 1 mm below the skinsurface for embodiments in which surface 1422 is configured to be incontact with a patient's skin) In one embodiment, the heights ofelements 1310 and 1420 are selected to be 1.5 mm. In some embodiments,lens 1420 is made of sapphire. This system can be used to target shallowskin structures that require high treatment fluence. For example, thelens system of FIG. 14 can be used to target psoriasis, sebaceousglands, hair shafts, or hair stem cells. FIG. 14B is a ray trace of oneexample of an embodiment of such an optical system 1400 having a source1220 and a collimator 1310 and an element 1420 as illustrated in FIG.14A.

FIG. 15A is a side view of another example of an embodiment of atwo-element cylindrical optical system 1500 appropriate for use withphotocosmetic devices according to some aspects of the presentinvention. FIG. 15 illustrates an optical system 1500 that can be used,for example, to focus the diode light deeper than the optical system1400 in FIG. 14. For example, optical system 1500 may focus the diodelight approximately 2 mm below the skin surface (i.e., 2 mm from surface1522) to target deep structures (e.g. hair bulb, deeper blood vessels,subcutaneous fat) in the skin.

System 1500 is a two-element symmetrical lens system to project lightfrom a source 1220. A first element 1510 is located approximately 1.4 mmfrom source 1220 and has a input surface 1511 that is planar and anoutput surface 1512 having curvature of 2.5 mm; accordingly, lens 1510quasi-collimates the light from light source 1522. A second lens 1520having an input surface 1521 with a curvature of 2.5 mm and a planaroutput surface 1522; accordingly lens 1522 focuses the quasi-collimatedlight 2 mm below the skin surface. In the illustrated embodiment,aberrations in the optical system are balanced to achieve asubstantially uniform (i.e., “flat top”) spatial optical intensityprofile at output surface 1522. The flat top intensity profile issubstantially determined by spherical aberration in a plane transverseto the cylindrical surface 1522. In some embodiments, lenses 1510 and1520 are made of sapphire. FIG. 15B is a ray trace of one example of anembodiment of such an optical system 1500 having a source 1220 and anelement 1510 and an element 1520 as illustrated in FIG. 15A.

FIG. 16A is a schematic illustration of an exemplary embodiment of ahead 1600 for performing photocosmetic procedures. Head 1600 isillustrated without a housing to facilitate description. As describedabove head 1600 will be moved along an area of a patient's skin,typically in direction 1602 or direction 1604.

Head 1600 includes an optical system 206 to transmit light from an EMRsource 1630. Electrodes 1620 activate an EMR source 1630. An electricinsulator 1650 may be located between electrodes 1620 to preventelectrical contact between electrodes 1620. Electrodes 1620 may betapered to reduce the region of contact with a patient's skin.

FIG. 16B is a schematic illustration of an exemplary embodiment of ahead 1650 for performing photocosmetic procedures that also provides thecapability to perform muscle stimulation during a photocosmeticprocedure. Electrical muscle stimulation is a well-known physicaltherapy procedure that may enhance the efficacy of some photocosmeticprocedures. For example, electrical muscle stimulation may be used toimprove the efficacy of wrinkle treatment or cellulite treatment.

In one embodiment, two electrodes 1610 for delivering the electricalstimulation are located on opposite sides of optical system 206, on aportion of head 1600 that is designed to be in contact with a patient'sskin during a photocosmetic treatment (i.e., during the delivery of EMRby system 206). One electrode 1610 contacts an area of a patient's skinprior to optical system 206 and the other electrode 1610 contacts anarea of skin after optical system 206.

A thermally conductive electric insulator 1615 (e.g., made of BeO ordiamond or other suitable material) can be used to prevent electricalcontact between electrodes 1610 which provide electrical stimulation,and electrodes 1620 which activate EMR source 1630. An electricinsulator 1650 may be located between electrodes 1620 to preventelectrical contact between electrodes 1620.

By applying a constant (or pulsed) electrical current to a patient'sskin via electrodes 1610 while the handpiece is scanned across the skinsurface, simultaneous muscle stimulation and electromagnetic treatmentcan be achieved. In some embodiments, electrodes may provide radiofrequency (RF) current through skin. Alternatively, electrodes, 1610 mayprovide a DC current or a microwave field. In some embodiments, skin canbe scanned with a RF current or microwave field to selectively heat aportion of skin to be treated with EMR radiation. Preheating skin mayenable the power of the EMR source 1630 to be decreased.

FIG. 17A is a schematic of one example of one embodiment of an apparatusaccording to some aspects of the invention, which determines contactbetween an optical element 1704 (e.g., element 1210 of FIG. 12) and thesurface of a patient's skin 1701. To provide eye safety, in someembodiments of photocosmetic devices, a contact sensor is used to enablean electromagnetic treatment source (e.g., source 510 of FIG. 5) toactivate only when the device is in contact with a patient's skin.

In FIG. 17A, an illumination source 1702 (e.g., diode laser or LED,separate from the treatment source) is mounted a few millimeters (e.g.,5 mm) away from element 1704, and directed toward skin surface 1701.Optionally, illumination source 1702 may be mounted to direct lighttoward skin surface 1701 through element 1704. Source 1702 may emitradiation at the same wavelength as the treatment source 510 butpreferably emits radiation at a different wavelength than the treatmentsource 510. A detector 1712 is located to detect light from theillumination source that is reflected or scattered from the surface ofskin 1701. Optionally, a filter 1708 may be added to selectivelytransmit light from source 1702, and to eliminate wavelengths of lightcorresponding to the treatment source 510 and any other extraneouswavelengths of light.

In the case of poor or no skin contact, a relatively large amount ofradiation light from source 1702 would reflect or scatter from the skinsurface 1701 through the optical system 1704 to detector 1712. Asillustrated in FIG. 17B, when element 1740 is in good contact with theskin surface 1701, scattering and absorption in the skin would attenuatelight from the illumination source 1702, and a relatively small amountof radiation would reach detector 1712. Thus, by using an electronicmeans (e.g., a comparator) to measure the output of detector 1712, andselecting an appropriate threshold, the treatment source can beconfigured to activate only when the output of detector 1712 is belowthe threshold. Optionally, source 1702 and/or detector 1712 may belocated in a base unit and one or more optical fibers may be used tocouple light from the handpiece to the source or detector.

In another embodiment, detector 1712 detects light from the treatmentsource to determine contact between element 1740 and skin surface 1701.In such a system, light from source 510 is scattered and reflected byskin surface 1701 through element 1704 to detector 1712. A radiationfilter 1708 may selectively transmit this scattered and reflectedradiation to detector 1712. In this embodiment, the treatment source 510is maintained at a low-power eye-safe mode until firm contact with theskin surface 1701 is made. When there is no or poor contact between skinsurface 1701 and element 1704, the output of detector 1712 is relativelylow. However, when element 1704 is in good contact with the skin surface1701, the output of detector 1701 is relatively high. Thus, treatmentsource 510 would be configured to fire only when the output of detector1712 was above a threshold level.

Alternatively, instead of source 1702 and detector 1712, a standardoptical contact detector that is in an optical computer system mouse canbe used, for example, the optical contact system in a CordLess Mouseman™produced by Logitech of Fremont, Calif.

As an alternative to the optical methods of determining contact,electrical methods can be used to detect contact between element 1704and a patient's skin 1701. FIG. 17C is a cross-sectional view ofhandpiece having two electrical contacts located in a portion of thehandpiece such that when element 1704 is in contact with skin 1701,contacts 1720 are also in contact with skin 1701. Contact can bedetermined by measuring resistance (or capacitance) between thecontacts. Treatment source 510 would be activated when resistance (orcapacitance) between contacts 1720 was within a selected range (i.e., arange typical for skin). In another embodiment, contacts 1720 may bemagnetic sensors to detect contact with skin surface 1701. In anotheralternative embodiment, contacts may be mechanical sensors to detectcontact with skin surface 1701. For example, one or more spring-loadedpins or buttons may be located such that when the element 1704 is incontact with the skin the pin or button is depressed. Multiple sensors,pins, buttons, or other mechanical sensors located around the perimeterof element 1704 could be used to help ensure that the entire surface ofelement 1704 face was in good contact with skin. Alternatively, contacts1720 can be conventional load cells to determine contact with skinsurface 1701. Contacts, sensors, pins, buttons, or other mechanicalsensors that allow for the measurement of resistance or capacitance maybe preferred to ensure that the contact is with skin and not withanother surface, for example, a mirror or countertop.

In another embodiment, one or more temperature sensors are used todetermine contact with skin surface 1701. A typical skin surfacetemperature is in the 30-32° C. range; accordingly temperature sensorscould be located near a surface of the device which contacts a patient'sskin, and contact could be determined to occur when the measuredtemperatures were within a selected range (e.g., 23-27° C.).Alternatively, contact could be determined to have occurred when thetemperature sensors measured a temperature versus time slope indicativeof contact. In still another embodiment, where lotion is to be dispensedon the skin (described above with reference to FIG. 11), skin contactcould be detected by using a pressure sensor within spray jet 1120. Thepressure sensor would measure the pressure needed to eject the lotiononto the skin. Only when the handpiece was in good contact with the skinwould relatively high pressure be provided to dispense the lotion.

Contact sensor designs are described in greater detail in U.S.application Ser. No. 09/847,043, by Henry Zenzie, filed Apr. 30, 2001,entitled “Contact Detecting Method and Apparatus for an OpticalRadiation Handpiece,” the substance of which is hereby incorporated byreference.

A handpiece is preferably scanned across a patient's skin within aspecified speed range. If the handpiece is moved too slowly (typicalminimum speed limit would be between 5 and 25 mm/s depending on theapplication), the light dosage will be too high and undesired thermaldamage may result. Correspondingly, if the handpiece is moved tooquickly (typically the maximum speed limit would be between 50 and 500mm/s depending on the application), the light dosage will be too low toachieve treatment efficacy. Thus, only when the handpiece is scannedwithin this speed range does the handpiece emit electromagneticradiation for treatment. An exemplary speed range for operation of aphotocosmetic hand piece for hair removal/growth delay is 10-500 mm/swhich corresponds to the speed ranges with which is approximately equalto the speed which a typical razors passes over their skin.

FIG. 18A is a cutaway side view of one embodiment of a handpiece 1800having a motion sensor 1820 for determining handpiece speed. Motionsensor 1820 may be used to prevent injury to skin 1810 by providingfeedback control to a treatment source (e.g., source 510 in FIG. 2),such that if the handpiece remains motionless or if the movement acrossthe skin 1810 is too slow or too fast, the intensity of source may bedecreased or increased, respectively, or the source may be turned off.Optionally, the treatment source may be disabled instead of reduced inpower. In one embodiment, a wheel 1821 is positioned to make physicalcontact with skin 1810, such that the wheel rotates as handpiece 1800 ismoved relative the skin 1810, and handpiece speed can be determined.

Handpiece 1800 may be configured to inform the operator when thehandpiece speed is inside or outside of an acceptable speed range. Forexample, a tactile indicator (e.g., a vibrator) could be configured tovibrate the handpiece when the handpiece speed is inside or outside thedesired range. Alternatively, a visual indicator 1804 (e.g., an LED) oran audio indicator (e.g., a beeper) may be used to inform the operatorthat the handpiece speed is inside or outside the desired range. In someembodiments, multiple indicators 1806 (e.g., LEDs having differentcolors, or different sound indicators) may be used to inform theoperator that the handpiece speed is either too high or too low or iswithin the desired range.

FIG. 18B is a schematic of one example of an embodiment of a motionsensor system having at least one wheel 1821. Preferably a second wheel1821 is added and located on an opposite side of optical system 206 toensure that the entire skin contacting surface of the optical system 206moves at a rate of speed within the acceptable range to provide uniformillumination on a patient's skin.

In one embodiment, each external wheel 1821 is coupled to acorresponding auxiliary internal wheel 1822 having perforations aroundits perimeter. A source 1830 projects light in the direction of acorresponding detector 1832 so that as a wheel 1821 rotates, theperforations of auxiliary wheel 1822 alternately transmit and blocklight projected by source 1830; as a result, as handpiece 1800 (visiblein FIG. 18A) moves across a patient's skin, detectors 1832 produce asignal having a chain of pulses.

One of ordinary skill would understand that the speed of the handpieceacross a patient's skin is proportional to the rate at which the pulsesoccur. A controller 1834 correlates the pulse rate to the handpiecespeed. The above-described perforated auxiliary wheel design is similarto a standard computer system mouse design, for example, a mouse wheelin the 3 Bth Wheel Mouse produced by Logitec Corporation of Fremont,Calif., which is just one example of an apparatus to measure handpiecespeed, many other apparatus are possible and are within the scope ofthis aspect of the invention. For example, in an alternative embodiment,a simple electric motor is coupled to wheel 1821 to generate a voltagethat is proportional to handpiece speed.

FIG. 19 illustrates another optical apparatus 1900 having a motionsensor for determining handpiece speed. In apparatus 1900, a lightsource 1902 (e.g. an infrared LED) is coupled into the transmittingfiber 1904. A light detector 1910 (e.g., an inexpensive CCD camera or adiode sensor) is coupled to the end of a receiving fiber 1906. Inapparatus 1900, the ends of the transmitting fiber 1904 and receivingfiber 1906 are coupled together to form a single fiber end 1909 that isin contact with the skin 1908. A portion of light projected onto skinsurface 1908 by transmitting fiber 1904 through fiber end 1908 isreflected or scattered from the skin surface 1908 and received byreceiving fiber 1906 through fiber end 1909 and detected by detector1910. Because the skin surface 1908 has a semi-periodic structure (e.g.,the distances between similar tissues such as hair follicle, vessels,glands are almost constant structure) detector output is modulated at arate dependent on the handpiece speed. One of ordinary skill wouldunderstand that handpiece speed can be calculated from the modulateddetector output. Optionally, a second transmitting fiber 1905 andreceiving fiber 1907 coupled together through fiber end 1911 may beadded, so that the first and second transmitting fiber/ receiving fiberpairs are located on opposite sides of optical system 206 to ensure thatthe entire skin-contacting surface of optical system 206 moves acrossthe skin with in the acceptable range to provide uniform illumination ona patient's skin.

In system 1900, each transmitting fibers 1904, 1905 is coupled to acorresponding receiving fiber 1906, 1907; alternatively, a transmittingfiber and corresponding receiving fiber, may contact the skin atdistinct, separated points (i.e., the transmitting fiber andcorresponding receiving fiber are not coupled at the skin); in such anembodiment, the ends of the fibers contacting the skin may be separatedby any distance at which photons scattered by tissue layers can bereliably detected. In such embodiments, the upper bound on the fiberspacing occurs when the light coupled into receiving fiber is reduced toa point at which the amount of scattered photons generates a signal thatis too small to be accurately detected.

Although optical apparatus for measuring handpiece speed have beendescribed, it should be understood that other methods of speedmeasurement are with the scope of this aspect of the invention. Forexample, electromagnetic apparatuses that measure handpiece speed byrecording the time dependence of electrical (capacitance andresistance)/magnetic properties of the skin as the handpiece is movedrelative the skin. Alternatively, the frequency spectrum or amplitude ofsound emitted while an object is dragged across the skin surface can bemeasured and the resulting information used to calculate speed becausethe acoustic spectrum is dependent on speed. Another alternative is touse thermal sensors to measure handpiece speed, by using two sensorsseparated by a distance along the direction in which the handpiece ismoved along the skin (e.g., one before the optical system and oneafter). In such embodiments, a first sensor monitors the temperature ofuntreated skin, which is independent of handpiece speed, and a secondsensor monitors the post-irradiation skin temperature; the slower thehandpiece speed, the higher the fluence delivered to a given area of theskin, which results in a higher skin temperature measured by the seconddetector. Therefore, the speed can be calculated based on thetemperature difference between the two sensors.

An alternative system to measure handpiece speed using thermalcharacteristics uses a heat source (e.g. the treatment source or anothermeans of heating an area of skin) located a selected distance from athermal sensor along the direction in which the handpiece is moved alongthe skin. In such embodiments, the handpiece speed can be determinedfrom the temperature measured by the thermal sensor. For a low handpiecespeed, the heat would have sufficient time to propagate through the skinfrom the heat source to the thermal sensor; however, at high speed theheat would not have time to reach the thermal sensor. Thus, a high skintemperature measured by the thermal sensor would indicate low speedwhereas a low skin temperature would indicate high speed.

In an alternative embodiment of a speed sensor, an optical apparatus isused to measure handpiece speed using Doppler-shift techniques. In sucha system, the wavelength of light from a probe laser is projected ontothe skin and the speed is determined by shifted frequency of a reflectedportion of the light.

In any of the above embodiments, a speed sensor may be used inconjunction with a contact sensor (e.g., a contact sensor as describedabove with reference to FIGS. 17A-17C). In one embodiment of ahandpiece, both contact and speed are determined by the same component.For example, an optical-mouse-type sensor such as is used on aconventional computer optical mouse may be used to determine bothcontact and speed. In such a system, a CCD (or CMOS) array sensor isused to continuously image the skin surface. By tracking the speed of aparticular set of skin features as described above, the handpiece speedcan be measured and because the strength of the optical signal receivedby the array sensor increases upon contact with the skin, contact can bedetermined by monitoring signal strength. Additionally, an opticalsensor such as a CCD or CMOS device may be used to detect and measureskin pigmentation level or skin type based on the light that isreflected back from the skin; a treatment may be varied according topigmentation level or skin type.

In some embodiments of the present invention, a motion sensor is used inconjunction with a feedback loop or look-up table to control theradiation source output. For example, the emitted laser power can beincreased in proportion to the handpiece speed according to a lookuptable. In this way, a fixed skin temperature can be maintained at aselected depth (i.e., by maintaining a constant flux at the skinsurface) despite the fact that a handpiece is moved at a range ofhandpiece speeds. The power used to achieve a given skin temperature ata specified depth is described in greater detail in U.S. patentapplication Ser. No. 09/634,981, which was incorporated by referenceherein above. Alternatively, the post-treatment skin temperature may bemonitored, and a feedback loop used to maintain substantially constantfluence at the skin surface by varying the laser output power. Skintemperature can be monitored by using either conventional thermalsensors or a non-contact mid-infrared optical sensor. The above motionsensors are exemplary; motion sensing can be achieved by other meanssuch as sound (e.g., using Doppler information).

Although the above embodiments were discussed with reference to a systemmonitoring handpiece speed as moved by an operator, the handpiece couldbe mounted on a translation stage to move the handpiece at controlled,predetermined speed across the skin surface. In such an embodiment, theapparatus would be positioned relative the patient to treat a selectedarea of skin, and the translation stage could be moved to a subsequentarea as necessary.

FIG. 20 is a schematic of one example of one embodiment of a handpiece2000 illustrating some aspects of a self-contained photocosmetic device.Handpiece 2000 includes an optical source 2055, a power supply 2047, anoptical system 2044, a cooling system 2046, and a speed and/or contactsensor 2048. The device is shown in contact with an area of skin 2043.Optical system 2044 couples light from light source 2055 into the skintreatment area 2043.

Cooling system 2046 can be a phase-change cooler or any otherappropriate cooling system. In some embodiments cooling system 2046 isin good thermal contact with the heatsink 2045 (or electrodes or othercooling surface, not shown). A power supply 2047 (e.g., battery orcapacitor) supplies electrical current to optical source 2055. Contactand/or speed sensor 2048 ensures safe and effective treatment asdescribed herein above. Although a contact and speed sensor isillustrated as a single component, it should be understood the contactand speed sensor may be different components and there may be multipleof each type of sensor as described above. Control electronics 2049process data from contact/speed sensors 2048 or other sensors (e.g.,thermal sensors) and control optical source 2055 and cooling system2046. Cooling system 2046 may be cooled prior to treatment via athermal-contact plate 2050. Power source 2047 may be charged viaelectrical contact 2051. On/off button 2052 controls the electricalpower. A housing 2053 may be used to enclose, protect, or mount one ormore of the above parts.

Optionally, a hair removal device 2054 may be located to remove hairprior to irradiation by light from optical source 2055 to ensure thatsubstantially no hair extends above the skin surface. For example, hairremoval device 2054 may be a blade razor (e.g., a safety razor, acartridge razor), an electric razor, a stripping device wherein the hairadheres to a surface and is pulled out as the handpiece is moved acrossa user's skin (e.g., a device like the Epilady™ produced by Happy Lady,Inc.), an abrasive device that grinds the hair, or a chemical compoundthat dissolves the hair. A hair removal device may be made disposablesuch that the hair removal device is easily replaceable by a user. Inthe instance of coarse hair, a razor having one or a plurality of bladesmay be used; however in the instance of fine hair, an abrasive paper maybe used. A body location having coarse hair initially may have fine hairafter one or more photocosmetic treatments; accordingly, a blade razormay be used for the first few treatments and an abrasive paper may beused for subsequent treatments. In some embodiments, the abrasive papermay be simply moved across the skin with a stroke of the photocosmeticdevice, and in other embodiments the paper may be vibrated by avibrating mechanism (e.g., a motor).

FIG. 21 is a schematic of one example of an embodiment of a handpiecedocking station 2100 for docking a handpiece 2000. Docking station 2100is contained in housing 2155. Power supply 2156 chargesbattery/capacitor 2047 via electrical contact 2051. Cooling material2046 is cooled by chiller 2157 (e.g., a Peltier element). For example,chiller 2157 may be used to recharge a cooling system, by condensing aphase change liquid or freezing a phase change solid. Heatsink 2058dissipates heat produced by chiller 2157. Heatsink 2058 may utilize gas,liquid, or solid (phase change) media for heat removal or may simply befins that are cooled by exposure to room temperature. Umbilical 2159contains wires to supply electrical power to the docking station from anelectrical outlet and may further include tubing for water cooling ofheatsink 2058. A self-contained photocosmetic device, and a handpiecedocking station are described in greater detail in U.S. application Ser.No. 60/292,827, filed Dec. 28, 2000, by G. Altshuler et al., entitled“Method and Apparatus for EMR Treatment,” the substance of which ishereby incorporated by reference.

For some embodiments of a photocosmetic device, it is advantageous tohave one or more replaceable components. For example, in someembodiments, where the handpiece will likely be dropped or otherwiseabused, it may be advantageous to make one or more optical systemsremovable from the handpiece. In addition, to achieve a variety oftreatments that each require different optical sources or opticalsystems (e.g., treatment of pigmented lesion removal and treatment toachieve hair removal), interchangeable optical components would permitthe user to perform different applications with the same handpiece.Additionally, for systems employing light sources or power sourceshaving a limited lifetime, replacement of the light sources at the endof useful life may be desirable.

FIG. 22 is a schematic of one example of one embodiment of a handpiece2200 having a detachable head 2210. Handpiece 2200 has a handle 2220coupled to a head 2210. Handle 2220 may be coupled to head 2210 usingany known method of fastening. Preferably head 2210 includes opticalcomponents (e.g., head 1600 of FIG. 16A) to facilitate the use ofreplaceable components.

FIG. 23 is a schematic of one example of an embodiment of a modularhandpiece 2300 having one or more components suitable for ease ofmanufacturablity and/or user-replacement. For example, handpiece 2300facilitates assembly and/or replacement of a head assembly 2310(including an optical system), a cooling assembly 2320, and a powerassembly 2330. Preferably, modular handpiece 2300 is configured suchthat when assembled, head assembly 2310 contacts a mating power plug ofpower assembly 2330.

FIG. 24 is a schematic illustrating an optical assembly 2400 including asource 2410 (e.g., two diode-laser-bars). The source 2410 may beincorporated into a user-replaceable disposable cartridge, includingelectrodes 2412, heat sink 2430, optical system 2420 and coupling plates2440. Coupling plates 2440 may be used to fasten optical system 2420,source 2410, and heat sink 2430. Preferably the fastening mechanism ofsource 2410 is configured to automatically align source 2410 to opticalsystem 2420. Also preferably, coupling plates are made of a materialhaving a good thermal conductivity (e.g., copper) to conduct heat fromthe optical system 2420. To simplify alignment of source 2410 andelement 2420, source 2412 may be fixedly mounted to optical system 2420.

In addition to replacing the source 2410 at the end of its useablelifetime, it may also be desirable to facilitate the user-replacement oflight sources 2410 for use for different cosmetic treatments withouthaving to purchase multiple handpieces. Furthermore, it may be desirableto facilitate user-replacement of light sources 2410 based on skin type,hair type and/or on the location of the area of skin to be treated(e.g., underarm, bikini, leg, face).

FIG. 25 is a schematic of one example of a photocosmetic device 2500illustrating some aspects of the present invention. Device 2500 has ahead 2580 and a handle 2590. Head 2580 has a first optical system 2510(e.g., optical system 310 in FIG. 3) to form a first area of radiation(e.g., area 311 in FIG. 3), and a second optical system 2515 (e.g.,optical system 315 in FIG. 3) to form a second area of radiation (e.g.,area 316 in FIG. 3) on a patient's skin. As described above withreference to FIG. 3, radiation to form the first area and the secondarea may be from a single divided source or two sources (sources notshown). Device 2500 also includes a motion sensor system having a wheel2521 (e.g., corresponding to wheel 1821 of FIG. 18), and a second wheel2522 (e.g., corresponding to wheel 1822 of FIG. 18) located on anopposite side of optical system 2510 to ensure that the entire skincontacting surface of the optical element 2510 moves at a rate of speedwithin the acceptable range to provide substantially uniformillumination on a patient's skin.

FIG. 26A is a schematic of one example of a photocosmetic head 2600illustrating aspects of the present invention directed to a treatingcurved area of skin (e.g., a jaw, back or arm). Head 2600 includes twopivoting transmission systems 2610 and 2620 for deliveringelectromagnetic radiation. The components of head 2600 are substantiallycontained within a housing 2630 and coupled to a base unit (not shown)via cord 2640. Housing 2630 is illustrated as a transparent wire frameto facilitate description. The size of components of head 2600 may beselected according to the body part with which they are to be used, andmultiple heads may be connectable to cord 2640 to permit treatment ofvarious body parts. Alternatively, each head may have a fixed cord suchthat each cord can be plugged into a base unit and removed.

FIG. 26B is a schematic of one embodiment of two transmission systems2610 and 2620 of a head to treat a curved surface. Transmission systems2610 and 2620 are illustrated without a housing to illustrate thererelative positioning. FIG. 26B illustrates that transmission systemspivot in at least one rotational direction to facilitate maintenance ofcontact with a curved area of skin. For example, transmission systems2610 and 2620 may be mounted at an angle relative to one another (e.g.,5-30 degrees) and mounted to enable rotation about axis X and X′.

FIG. 27 is a schematic illustrating an embodiment of some aspects ofhandpiece 2700 according to the present invention. Handpiece 2700includes a housing 2710 having a handle 2702 and a head 2704. Handpiece2700 includes a head assembly 2710 (including an optical system), acooling assembly 2720, and a power assembly 2730.

FIG. 28 is a schematic illustration of one embodiment of a photocosmeticdevice 2800 according to at least some aspects of the present invention.Device 2800 includes a handpiece 2810, a base unit 2820, a cord 2826 tocouple handpiece 2810 to base unit 2820. Handpiece 2810 may be graspedby an operator to move a head 2830 across a patient's skin (not shown).Head 2830 may be any head as described herein above or any othersuitable head to achieve a photocosmetic treatment, for example, any ofthe treatments described below.

The following is a discussion of examples of treatments that can beachieved using apparatus and methods according the present invention;however, the treatments discussed are exemplary and are not intended tobe limiting. Apparatus and methods according the present invention areversatile and may be applied to any known or yet-to-be-developedtreatments.

Exemplary treatment mechanisms include absorption of light by achromophore within a tissue responsible for the unwanted cosmeticcondition or by a chromophore in proximity to the tissue. Treatment maybe achieved by limited heating of the target tissue below temperature ofirreversible damage or may be achieved by heating to cause irreversibledamage (e.g., denaturation). Treatment may be achieved by directstimulation of biological response to heat, or by induction of a cascadeof phenomena such that a biological response is indirectly achieved byheat. A treatment may result from a combination of any of the abovemechanisms. Optionally, cooling, DC or AC (RF) electrical current,physical vibration or other physical stimulus/action may be applied to atreatment area or adjacent area to increase the efficacy of a treatment.A treatment may result from a single session, or multiple sessions maybe used to achieve a desired clinical effect.

A device according to one or more aspects of the invention may operatein a variety of optical ranges. For example, electromagnetic radiationdelivered to the skin may have wavelength within the range 380-1900 nm.The power of the light delivered may be in the range 0.001-300 W/cm, andexemplary scan speeds include 0.1-500 mm/sec. The desired radiationcharacteristics may be achieved by any suitable LEDs, lamps, and diodelasers or any other suitable light source presently available oryet-to-be developed.

Radiation-induced hair removal is a cosmetic treatment that could beperformed by apparatus and methods according to aspects of the presentinvention. In the case of hair removal, the principal target for thermaldestruction is the hair bulb and preferably the hair matrix, hairpapilla or basement membrane of the bulb. For hair removal treatments,melanin located in the hair shaft and follicle is the targetedchromophore. While the bulb contains melanin and can thus be thermallytreated, the basement membrane, which provides the hair growthcommunication pathway between the papilla within the bulb and the matrixwithin the hair shaft, contains the highest concentration of melanin andmay be selectively targeted.

Wavelengths between 0.6 and 1.2 μm are typically used for hair removal.By proper combination of power, speed, and focusing geometry, differenthair related targets (e.g., bulb, matrix, basement membrane, stem cells)can be heated to the denaturation temperature while the surroundingdermis remains undamaged. Since the targeted hair follicle and theepidermis both contain melanin, a combination of epidermal contactcooling and long pulsewidth can be used to prevent epidermal damage. Amore detailed explanation of hair removal is given in co-pendingprovisional patent application No. 60/363,871, entitled “METHOD ANDAPPARATUS FOR HAIR GROWTH CONTROL,” by Rox Anderson, et al. filed Mar.12, 2002, which is hereby incorporated herein by reference.

Hair removal is often required over large areas (e.g. back and legs),and the required power is therefore correspondingly large (on the orderof 20-500 W) in order to achieve short treatment times. Currentgeneration diode bars are capable of emitting 40-60 W at 800 nm, whichmakes them effective for use in some embodiments of photocosmetic deviceaccording to the present invention.

Exemplary methods of hair growth management may be achieved by combininglow power irradiation of hair follicles with light and physicalextraction of hair shaft, and/or complete or non-complete physicalextraction of the hair follicle from the body. According to someembodiments irradiation is achieved by irradiating a portion of the skincontaining the hair follicle with a light source emitting at a range ofwavelengths absorbed by melanin or other endogenous or exogenouschromophores in the follicle. Physical extraction can be performed bymechanical, electromechanical or other suitable techniques. Thistreatment can be used for either temporary hair reduction or permanenthair reduction.

A first exemplary embodiment of a method of hair growth managementaccording to the present invention includes first physically removinghair (“depilation”) and then irradiating the skin as described above.According to some embodiments, the hair removal can be adjusted toremove mostly hair shafts from hair follicles; alternatively hairremoval may be down to keratinoized zone. This depilation can be done byelectromechanical depilation or waxing.

Phototreatment can be performed, for example, using one of theembodiments of photocosmetic device described above. According to theseembodiments, light is absorbed by melanin in hair matrix and as a resultof thermal injury hair growth is decelerated or completely arrested.

Optionally, after depilation but before irradiation, a topical lotioncan be applied to the skin (e.g., via the handpiece) in a treatment areato fill empty hair follicles corresponding to the removed hair. In someembodiments, the transparent lotion is selected to have a refractiveindex in a range suitable to provide a waveguide effect to direct thelight to a region of the skin to be irradiated. Preferably the index ofrefraction of the lotion is higher than the index of refraction of water(i.e., approximately 1.33 depending on chemical additives of the water).In some embodiments, the index of refraction of the lotion is higherthan the index of refraction of the dermis (i.e., approximately 1.4). Insome embodiments, the index of refraction of the lotion is higher thanthe index of refraction of the inner root sheath (i.e., approximately1.55). In embodiments where the index of refraction is greater than theindex of refraction of the inner root sheath, light incident on thesurface of the skin can be delivered directly to hair matrix withoutsignificant attenuation.

The effective pulse length used to irradiate the skin is given by thebeam size divided by the speed of scanning of the irradiation source.For example, a 2 mm beam size moved at a scanning speed of 50-100 mm/sprovides an effective pulse length of 20-60 ms. For a power density of250 W/cm the effective fluence is 5-10 J/cm², which approximatelydoubles the fluence of the light delivered by a device without the useof a high index lotion.

In some embodiments, the pH of the lotion can be adjusted to decreasethe denaturation threshold of matrix cells. In such embodiments, lowerpower is required to injure the hair matrix and thus provide hair growthmanagement. Optionally, the lotion can be doped by molecules or ions oratoms with significant absorption of light emitted by the source. Due toincreased absorption of light in hair follicle due to the lotion, alower power irradiation source may be used to provide sufficientirradiation to heat the hair matrix.

A second exemplary embodiment of a method of hair growth managementaccording to the present invention includes first irradiating the skin,and then physically removing hair as described above. By firstirradiating the skin, attachment of the hair shaft to the follicle orthe hair follicle to dermis is weakened. Consequently, mechanical orelectromechanical depilation may be more easily achieved (e.g., by usinga soft waxing or electromechanical epilator) and pain may be reduced.

Irradiation can weaken attachment of hair bulb to skin or subcutaneousfat; therefore it is possible to pull out a significantly higherpercentage of the hair follicle from the skin compared to the depilationalone. Because the diameter of the hair bulb is close to the diameter ofthe outer root sheath, pulling out hair with hair bulb can permanentlydestroy the entire hair follicle including stem cells. Accordingly, byfirst irradiating and then depilating, new hair growth can be delayed orterminated.

Treatment of cellulite is another example of a cosmetic problem that maybe treated by apparatus and methods according to aspects of the presentinvention. The formation of characteristic cellulite dimples begins withpoor blood and lymph circulation, which in turn inhibits the removal ofcellular waste products. For example, unremoved dead cells in theintracellular space may leak lipid over time. Connective tissue damageand subsequent nodule formation occurs due to the continuingaccumulation of toxins and cellular waste products.

The following are two exemplary treatments for cellulite, both of whichaim to stimulate both blood flow and fibroblast growth. In a firstexemplary treatment, localized areas of thermal damage are created usinga treatment source emitting in the near-infrared spectral range (e.g.,at a wavelength in the range 650-1850 nm) in combination with an opticalsystem designed to focus 2-10 mm beneath the skin surface. In oneembodiment, light having a power density of 1-100 W/cm is delivered tothe skin surface, and the apparatus is operated at a speed to create atemperature of 45 degrees Celsius at a distance 5 mm below the skin.Cooling may be applied to avoid or reduce damage to the epidermis toreduce wound formation. Further details of achieving a selectedtemperature a selected distance below the skin is given in U.S. patentapplication Ser. No. 09/634,691, filed Aug. 9, 2000, the substance ofwhich was incorporated by reference herein above. The treatment mayinclude compression of the tissue, massage of the tissue, or multipassesover the tissue.

In a second exemplary treatment, a treatment source emittingnear-infrared light (e.g., a light emitting diode emitting at awavelength in the range 700-1300 nm) is used to focus the light adistance 2-10 mm beneath the skin surface, to elevate thedermis/subcutaneous fat temperature to a point well below the thermaldamage threshold (e.g., a temperature in the range 42-60 degreeCelcius). According to the second exemplary treatment, heating mayincrease the rate of lipolysis (i.e., fat breakdown) and cause apoptosis(i.e., programmed cell death) of fat cells. Optionally, a topicallipolytic cream may be used in combination with the second exemplarytreatment; the elevated temperature profile in the dermis/subcutaneousfat may enhance cream penetration and thus increase its efficacy. Due tovery long thermal relaxation time of subcutaneous fat (i.e., longer than1 minute), multiple scanning treatments of an area can achieve thedesired heating of the fat, while maintaining normal skin surfacetemperature. The above exemplary treatments may be used for fatmetabolism activation and fat reduction.

Acne is another very common skin disorder that can be treated usingapparatus and methods according to aspects of the present invention.Acne results when sebum from the sebaceous gland cannot reach the skinsurface via the hair follicle, and a bacterial infection occurs withinthe hair follicle. Photocosmetic treatment is an alternative totraditional treatments (e.g., topical and oral medications).

The following are exemplary methods of treating acne according to thepresent invention. In each of the exemplary methods, the actual treatedarea may be relatively small (assuming treatment of facial acne), thus alow-power CW source may be used. A first possible treatment is toselectively damage the sebaceous gland to prevent sebum production. Thesebaceous glands are located approximately 1 mm below the skin surface.By creating a focal spot at this depth and using a wavelengthselectively absorbed by lipids (e.g., in proximity of 0.92, 1.2, and 1.7μm), direct thermal destruction becomes possible. For example, to causethermal denaturation, a temperature of 45-65 degrees Celsius may begenerated at approximately 1 mm below the skin surface using any of themethods described in U.S. patent application Ser. No. 09/634, 691, filedAug. 9, 2000, the substance of which was incorporated by referenceherein above.

Optionally, a linear matrix of focal spots (as described above withreference to FIG. 4) may be used to create islands of damage. Althoughthe exact position of the sebaceous glands may not be known, eachtreatment with a matrix of focal spots will result in a certain numberof sebaceous glands being damaged. Thus, by treating the area multipletimes, a significant number of sebaceous glands will be damaged.

An alternative treatment for acne involves heating a sebaceous gland toa point below the thermal denaturation temperature (e.g., to atemperature 45-65 degrees Celsius) to achieve a cessation of sebumproduction and apoptosis (programmed cell death). Such selectivetreatment may take advantage of the low thermal threshold of cellsresponsible for sebum production relative to surrounding cells. Anotheralternative treatment of acne is thermal destruction of the blood supplyto the sebaceous glands (e.g., by heating the blood to a temperature60-95 degrees Celsius).

For the above treatments of acne, the sebaceous gland may be sensitizedto near-infrared radiation by using compounds such as indocyanine green(ICG, absorption near 800 nm) or methylene blue (absorption near 630nm). Alternatively, non-thermal photodynamic therapy agents such asphotofrin may be used to sensitize sebaceous glands. In someembodiments, biochemical carriers such as monoclonal antibodies (MABs)may be used to selectively deliver these sensitization compoundsdirectly to the sebaceous glands.

Although the above procedures were described as treatments for acne,because the treatments involve damage/destruction of the sebaceousglands (and therefore reduction of sebum output), the treatments mayalso be used to treat excessively oily skin.

Another light-based method of treating acne involves thermallydestruction of the bacteria (P. acnes) responsible for thecharacteristic inflammation associated with acne. Destruction of thebacteria may be achieved by targeting porphyrins stored in P. AcnesPorphyrines, such as protoporphyrins, coproporphyrins, andZn-protoporphyrins are synthesized by anaerobic bacteria as theirmetabolic product. Porphyrines absorbs light in the visible spectralregion from 400-700 nm, with strongest peak of absorption around 415 nm.By providing light in the selected wavelength ranges in sufficientintensity heat resulting from absorption causes death of the bacteria.For example, the desired effect may be achieved using a treatment sourceemitting at a wavelength in the range 360-700 nm using an optical systemdesigned to focus 0.2 −1 mm beneath the skin surface and a power densityof 0.01-10 W/cm at the skin surface.

Yet another technique for treating acne involves using light to expandthe opening of an infected hair follicle to allow unimpeded sebumoutflow. In one embodiment of the technique, a lotion thatpreferentially accumulates in the follicle opening (e.g., lipidconsistent lotion with organic non organic dye or absorption particles)is applied to the skin surface. A treatment source wavelength is matchedto an absorption band of the lotion. For example, in the case of ICGdoped lotion the source wavelength is 790-810 nm. By using an opticalsystem to generate a temperature of 45-100 degrees Celsius at theinfundibulum/infrainfundibulum, for example, by generating a fluence ofat skin surface (e.g., 1-100 W/cm), the follicle opening can be expandedand sebum is allowed to flow out of the hair follicle and remodeling ofinfrainfundibulum in order to prevent comedo (i.e., blackhead)formation.

Non-ablative wrinkle treatment, which is now used as an alternative totraditional ablative CO₂ laser skin resurfacing, is another cosmetictreatment that could be performed by apparatus and methods according toaspects of the present invention. Non-ablative wrinkle treatment isachieved by simultaneously cooling the epidermis and delivering light tothe upper layer of the dermis to thermally stimulate fibroblasts togenerate new collagen deposition.

In wrinkle treatment, because the primary chromophore is water,wavelengths ranging from 0.8-2 μm appropriate wavelengths of treatmentradiation. Since only wrinkles on the face are typically of cosmeticconcern, the treated area is typically relatively small and the requiredcoverage rate (cm²/sec) is correspondingly low, and a relativelylow-power treatment source may be used. An optical system providingsub-surface focusing in combination with epidermal cooling may be usedto achieve the desired result. Precise control of the upper-dermistemperature is important; if the temperature is too high, the inducedthermal damage of the epidermis will be excessive, and if thetemperature is too low, the amount of new collagen deposition will beminimal. A speed sensor (in the case of a manually scanned handpiece) ora mechanical drive may be used to precisely control the upper-dermistemperature. Alternatively, a non-contact mid-infrared thermal sensorcould be used to monitor dermal temperature.

Vascular lesions (e.g. port-wine stains, rosacea, spider veins) presentanother cosmetic problem that could be treated by apparatus and methodsaccording to aspects of the present invention. For treatment of vascularlesions, the target chromophore is blood in these lesions. Exemplarytreatment wavelengths range from 0.4-0.6 μm for superficial vascularlesions and 0.6-1.3 for deep vascular lesions. In the case of treatmentof spider veins, the relatively large size and corresponding longthermal relaxation time of the target tissue requires a large depositionof energy over a long time period to achieve thermal destruction and topreserve the epidermis. In addition, aggressive epidermal cooling(particularly for patients with darker skin type IV-VI) can be used toprevent epidermal damage. The use of CW sources is advantageous in thetreatment of lesions because, similar to hair removal, part of thetargeted structure (vein wall) contains little blood and must be damagedby thermal diffusion.

Pigmented lesions such as age spots can be removed by selectivelytargeting the cells containing melanin in these structures. Theselesions are located using an optical system focusing at a depth of100-200 μm below the skin surface and can be targeted with wavelengthsin the 0.4-1.1 μm range. Since the individual melanin-bearing cells aresmall with a short thermal relaxation time, a shallow sub-surface focusis helpful to reach the denaturation temperature.

Elimination of underarm odor is another problem that could be treated byan apparatus and methods according to aspects of the present invention.In such a treatment, a source having a wavelength selectively absorbedby the eccrine/apocrine glands is used to thermally damage theeccrine/apocrine glands. Optionally, a sensitization compound may beused to enhance damage.

Tattoo removal is another procedure that can be achieved by apparatusand methods according to aspects of the present invention. Conventionaldevices for tattoo removal include short pulsed (10-50 ns) Q-switchedruby, alexandrite, Nd:YAG and frequency-doubled Nd:YAG for cosmetictattoo removal. Typically, a source wavelength is selected based on thecolor of the tattoo to be removed (e.g., a green laser is used to removea red portion of a tattoo). Since the ink particles are actuallyincorporated into individual cells, one embodiment of a thermaltreatment for tattoo removal cause the rupture of the cells, therebyreleasing the ink.

Exemplary embodiments of apparatus according to aspects of the presentinvention for use in tattoo removal use a CW source, and an opticalsystem selected to tightly focus radiation from a treatment source atthe depth where the cells containing the ink particles reside (e.g.,150-700 μm) to rupture the ink-containing cells. Alternatively, it mayalso be possible to heat the cells below their thermal denaturationpoint and induce apoptosis. In the case of embodiments designed to causeapoptosis, healing may be enhanced by operating the radiation source ina quasi-continuous mode while the handpiece is continuously scannedacross the skin surface to create areas in which cells are damaged andareas of non-irradiated areas in between. In some embodiments, feedbackfrom a speed sensor could be used to control laser emission and createequally spaced lines of damage independent of handpiece speed. Tocompletely remove the tattoo, multiple treatments would be required.

In some conventional, relatively expensive tattoo-removal apparatus, aQ-switched frequency-doubled Nd:YAG laser emitting at 0.532 μm iscombined with an (Nd:YAG) emitting at 1.064 μm, and alexandrite laseremitting at 0.755 μm; the lasers are selectively operated to targetcells containing various tattoo ink colors. Embodiments of modularapparatus according to aspects of the present invention, provide arelatively low-cost alternative to the above system. For example, anembodiment of the present invention may be configured to allow the useof optical sources emitting at distinct wavelengths or wavelength bandsor a single source and optical components to modify the wavelength ofthe light generated by a source. In particular, to achieve a wavelengthclose to the 0.755 μm wavelength, a 0.808 μm diode laser bar may beused; and a Nd:YAG crystal module could be inserted into the handpiecethat would be pumped by the diode laser bar to produce a wavelengthclose to the 1.064 μm wavelength; and to produce a wavelength close tothe 0.532-μm wavelength, an SHG crystal may be used to double thefrequency of a laser diode emitting 1.064 μm wavelength radiation.Alternatively, a self-frequency-doubling crystal such as Nd:YCOB may beused.

Low-intensity therapy (LIT) is another procedure that can be achieved byapparatus and methods according to aspects of the present invention. LITmay be used to for treatment of wounds, carpal-tunnel syndrometreatment, or to stimulate hair growth, or to accelerate biochemicalreactions. Power densities and wavelengths (630-820 nm) typically usedfor LITs may be achieved using diode lasers or LED treatment sources.Optionally one or more of the above treatments may be used forveterinary LIT applications.

Elimination of or reduction of the prominence of stretch marks and scarsare procedures that may be achieved using apparatus and methodsaccording to aspects of the present invention. Similar to the case ofnon-ablative skin resurfacing, to achieve the above procedures, it maybe possible to stimulate collagen deposition and wound healing bycreating a thin thermally damaged layer in the upper dermis.

Removal of warts is another procedure that can be achieved usingapparatus and methods according to aspects of the present invention.Wart removal may be achieved using a source producing light in theregion of blood absorption (0.5-0.8 μm). This wavelength is selectivelyabsorbed by hemoglobin, which appears to shuts off the wart's bloodsupply.

Psoriasis is skin disorder that can be treated using apparatus andmethods according to aspects of the present invention. Exemplary,embodiments of the present invention configured to treat psoriasis emitat wavelengths near 800 nm. Optionally, one or more sensitization agentssuch as photodynamic drugs or ICG/Methylene blue may be used. Treatmentmay be applied several times per week, and may be delivered in severaldifferent ways including islands (or lines) of treatment. Additionalapplication of apparatus and methods according to aspects of the presentinvention include facilitation of delivery of topical medications andcosmetic preparations into skin.

Having thus described the inventive concepts and a number of exemplaryembodiments, it will be apparent to those skilled in the art that theinvention may be implemented in various ways, and that modifications andimprovements will readily occur to such persons. Thus, the examplesgiven are not intended to be limiting. The invention is limited only asrequired by the following claims and equivalents thereto. The inventionis limited only as required by the following claims and equivalentsthereto. Also, it is to be understood that the use of the terms“including,” “comprising,” or “having” is meant to encompass the itemslisted thereafter and equivalents thereof as well as additional itemsbefore, after, or in-between the items listed.

What is claimed is:
 1. A device for measuring the pigmentation level ofskin, comprising: a handpiece adapted for contact with the skin; a lightsource configured to illuminate the skin; a contact sensor coupled tothe handpiece, wherein the contact sensor is capable of determining ifthe handpiece is in contact with the skin; and an optical sensor coupledto the handpiece, wherein the optical sensor measures illuminationreflected from the skin and is configured to calculate and output skinpigmentation level based on the measurement of illumination reflectedfrom the skin, and wherein pigmentation level measurement is enabledwhen the contact sensor detects contact between the handpiece and theskin.
 2. The device of claim 1, wherein the optical sensor is at leastone of a CCD or a CMOS device.
 3. The device of claim 1, wherein thecontact sensor is at least one of an optical sensor, an electricalsensor, a mechanical sensor, and a temperature sensor.